76066-86-9

Upstream product

• 41867-20-3 ethyl (E)-3-aminobut-2-enoate 
• 83-13-6 diethyl 2-phenylmalonate 
• 626-34-6 ethyl aminocrotonate 
• 626-34-6 ethyl 3-aminobut-2-enoate 

Downstream Products

• 24555-55-3 4-hydroxy-6-methyl-3-phenylpyridin-2(1H)-one 
• 38468-80-3 4-hydroxy-6-methyl-2-oxo-3-phenyl-1,2-dihydropyridin-5-carboxylic acid 
• 138485-28-6 6-methyl-3-phenyl-4-trifluoroacetylamino-pyridin-2(1H)-one 
• 138485-25-3 4-benzylamino-6-methyl-3-phenylpyridin-2(1H)-one 
• 138485-27-5 4-acetylamino-6-methyl-3-phenylpyridin-2(1H)-one 
• 138485-26-4 4-amino-6-methyl-3-phenylpyridin-2(1H)-one 

Relevant academic research and scientific papers

4-Hydroxyquinolones-2. 91. Synthesis and properties of ethyl 1-R-4-hydroxy-6-methyl-2-oxo-dihydropyridine-5-carboxylates

The reaction of ethyl aminocrotonates with derivatives of malonic acid is a suitable method for the preparation of ethyl 4-hydroxy-6-methyl-2-oxo-1,2- dihydropyridine-5-carboxylates. One of the synthesized materials has been studied by X-ray crystallograp

Thermal Cyclization of 3-Acyl-4-azidopyridines to Isoxazolo[4,3-c]pyridines

4-Azidopyridines such as 3-acetyl-4-azido-2-pyridones 3 or 4-azido-3-ethoxycarbonylpyridine 7 with reactive ortho-acyl substituents were obtained from the 4-hydroxy-2-pyridones 1, resp. 5 via 4-tosyloxy-2-pyridones 2 or the 2,4-dichloropyridine 6. DSC-ass

Anti-mycobacterial 4-hydroxy-3-phenylpyridin-2(1H)-ones

4-Hydroxy-3-phenylpyridin-2 (1H)-ones with different substituents either at N-1 or in the phenyl group were synthesized by reaction of ethyl β-aminocrotonates with dialkyl malonates or 'magic malonates' (2,4,6-trichlorophenyl malonates).The evaluation of these compounds on Mycobacterium tuberculosis H37Ra, Escherichia coli B and Staphylococcus aureus ATCC 25923 showed significant inhibitory effects on M tuberculosis (5g and 5s, MIC=8μg/ml).A structure-activity relationship is discussed.