245741-72-4Relevant academic research and scientific papers
Synthesis of C1-C8 and C9-C24 fragments of (-)-discodermolide: Use of asymmetric alkylation and stereoselective aldol reactions
Filla, Sandra A.,Song, Jinhua J.,Chen, Lihren,Masamune, Satoru
, p. 5449 - 5453 (1999)
The C1-C8 and C9-C24 fragments of (-)-discodermolide, the antipode of the marine natural product (+)-discodermolide, have been synthesized with excellent stereoselectivities. These syntheses feature the utilization of the isoxazolidine-mediated asymmetric alkylation methodology and fragment- fragment coupling aldol reactions.
