Synthesis of C1-C8 and C9-C24 fragments of (-)-discodermolide: Use of asymmetric alkylation and stereoselective aldol reactions

Article abstract of DOI:10.1016/S0040-4039(99)01009-6

The C1-C8 and C9-C24 fragments of (-)-discodermolide, the antipode of the marine natural product (+)-discodermolide, have been synthesized with excellent stereoselectivities. These syntheses feature the utilization of the isoxazolidine-mediated asymmetric alkylation methodology and fragment- fragment coupling aldol reactions.