245748-21-4

Basic information

• Product Name: 5-(furan-2-yl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole
• Synonyms: 5-(furan-2-yl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole
• CAS NO: 245748-21-4
• Molecular Weight: 323.231
• Mol File: 245748-21-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(furan-2-yl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(furan-2-yl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole(245748-21-4)
• EPA Substance Registry System: 5-(furan-2-yl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole(245748-21-4)

Safety Data

• Hazardous Substances Data: 245748-21-4(Hazardous Substances Data)

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 904733-74-0 5-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazole 
• 326-90-9 4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione 
• 100-16-3 4-nitrophenylhydrazone 

Downstream Products

• 245748-23-6 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid 
• 245748-64-5 (2-{4-[(3-fluoro-pyridine-4-carbonyl)-amino]-phenyl}-5-trifluoromethyl-2H-pyrazol-3-yl)-carbamic acid tert-butyl ester 
• 1028289-25-9 N-[4-(5-amino-3-trifluoromethyl-pyrazol-1-yl)-phenyl]-3-fluoro-isonicotinamide 
• 245748-41-8 tert-butyl 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-ylcarbamate 
• 245748-42-9 [2-(4-amino-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-carbamic acid tert-butyl ester 
• 245748-25-8 N-methoxy-N-methyl-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 245748-26-9 1-(4-aminophenyl)-N-methoxy-N-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 
• 245748-27-0 1-[1-(4-aminophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1-ethanone 

Relevant articles and documents

Novel Anthranilic Diamide Scaffolds Containing N-Substituted Phenylpyrazole as Potential Ryanodine Receptor Activators

To discover potent insecticides targeting ryanodine receptors (RyRs), a series of novel anthranilic diamides analogues (12a-12u) containing N-substituted phenylpyrazole were designed and synthesized. These compounds were characterized by 1H NMR, 13C NMR, and HRMS, and the structure of compound 12u was confirmed by X-ray diffraction. Their insecticidal activities indicated that these compounds displayed moderate to excellent activities. In particular, 12i showed 100 and 37% larvicidal activities against oriental armyworm (Mythimna separata) at 0.25 and 0.05 mg L-1, equivalent to that of chlorantraniliprole (100%, 0.25 mg L-1; and 33%, 0.05 mg L-1). The activity of 12i against diamondback moth (Plutella xylostella) was 95% at 0.05 mg L-1, whereas the control was 100% at 0.05 mg L-1. The calcium-imaging technique experiment results showed that the effects of 12i on the intracellular calcium ion concentration ([Ca2+]i) in neurons were concentration-dependent. After the central neurons of Helicoverpa armigera were dyed by loading with fluo-5N and treated with 12i, the free calcium released in endoplasmic reticulum indicated the target of compound 12i is RyRs or IP3Rs. The activation of RyRs by natural ryanodine completely blocked the calcium release induced by 12i, which indicated that RyRs in the central neurons of H. armigera third-instar larvae is the possible target of compound 12i.

3,5-Bis(trifluoromethyl)pyrazoles: A novel class of NFAT transcription factor regulator

A series of bis(trifiuoromethyl)pyrazoles (BTPs) has been found to be a novel inhibitor of cytokine production. Identified initially as inhibitors of IL-2 synthesis, the BTPs have been optimized in this regard and even inhibit IL-2 production with a 10-fold enhancement over cyclosporine in an ex vivo assay. Additionally, the BTPs show inhibition of IL-4, IL-5, IL-8, and eotaxin production. Unlike the IL-2 inhibitors, cyclosporine and FK506, the BTPs do not directly inhibit the dephosphorylation of NFAT by calcineurin.