24589-68-2Relevant academic research and scientific papers
Synthesis and catalytic properties of diverse chiral polyamines
Levine, Mindy,Kenesky, Craig S.,Zheng, Shengping,Quinn, Jordan,Breslow, Ronald
, p. 5746 - 5750 (2008/12/22)
Chiral polyamines can be utilized for a variety of potential applications, ranging from asymmetric catalysis to nonviral gene delivery systems for DNA and RNA. They can also be utilized to solubilize carbon nanotubes. Thus, methods for the straightforward synthesis of chiral polyamines are needed. We present herein two synthetic strategies for accessing chiral polyamines. The potential of these chiral amines to catalyze two organic reactions with a high degree of chiral induction was also explored.
Process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines
-
, (2008/06/13)
A process for the optical resolution of racemic 1,4-dihydropyridines, containing isothioureido groups. Salification of racemic isothioureas with optically active acids produces diasteroisomeric mixtures of isothiouronium salts, that, using conventional techniques, are separated in the individual components to give optically pure isothioureides of 1,4-dihydropyridines and salts thereof with conventional acids. Said optically pure 1,4-dihydropyridines can then be subjected to desulphuration and to different transformations to give to other enantiomerically pure and therapeutically useful 1,4-dihydropyridines.
