504-77-8

Usage

Uses

Used in Pharmaceutical Industry:
4,5-dihydrooxazole is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
4,5-dihydrooxazole is used as a starting material for the preparation of 2,4-Diaryloxazolines, which are known for their insecticidal and acaricidal properties. These compounds are utilized in the development of effective insecticides and acaricides to protect crops and control pests in the agricultural sector.
Used in Chemical Synthesis:
Due to its reactive nature, 4,5-dihydrooxazole can be employed as a building block in the synthesis of various organic compounds. Its versatility makes it a valuable component in the creation of new molecules with potential applications in different industries, such as materials science, pharmaceuticals, and agrochemicals.

InChI:InChI=1/C3H5NO/c1-2-5-3-4-1/h3H,1-2H2

Upstream product

• 24589-68-2 N-(2-chloroethyl)formamide 
• 693-06-1 (2-hydroxyethyl)-formamide 
• 119072-55-8 tert-butylisonitrile 
• 141-43-5 ethanolamine 

Downstream Products

• 130776-11-3 [1S-[1α,2α(Z),3α,4α]]-7-[3-[4-[[(4-Cyclohexylbutyl)amino]carbonyl]-2-oxazolyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid, methyl ester 
• 130775-92-7 [1S-[1α,2α(Z),3α,4α]]-6-[3-[4-[[[2-(4-Chlorophenyl)ethyl]amino]carbonyl]-2-oxazolyl]-7-oxabicyclo[2.2.1]hept-2-yl]-4-hexenoic acid, methyl ester 
• 130775-90-5 [1S-[1α,2α(Z),3a,4a]]-6-[3-[4-[[(2-Cyclohexylethyl)amino]carbonyl]-2-oxazolyl]-7-oxabicyclo[2.2.1]hept-2-yl]-4-hexenoic acid, methyl ester 
• 492-38-6 2-phenylacrylic acid 
• 67305-72-0 1-(2-mercaptoethylamino)-1-propanone 
• 288089-62-3 (4S)-4,5-dihydro-4-(1,1-dimethylethyl)-2-phenyloxazole 
• 288-42-6 oxazol 
• 30093-97-1 3,4,4-trimethyl-Δ²-oxazolinium iodide 
• 103863-14-5 4-phenyl-3-pyridinecarboxylic acid 

Relevant academic research and scientific papers

The dissociation chemistry of low-energy N-formylethanolamine ions: Hydrogen-bridged radical cations as key intermediates

Tandem mass spectrometry experiments show that N-formylethanolamine molecular ions HOCH2CH2NHC(H)O+ (FE1) lose C2H3O, CH2O and H2O to yield m/z 46 ions HC(OH)NH2+, m/z 59 ions CH2N(H)CHOH +, and m/z 71 N-vinylformamide ions CH2C(H)N(H)CHO +. A detailed mechanistic study using the CBS-QB3 model chemistry reveals that the readily generated 1,5-H shift isomer HOCHCH2N(H)C(H) OH+ (FE2) and hydrogen-bridged radical cations (HBRCs) act as key intermediates in a 'McLafferty + 1′ type rearrangement that yields the m/z 46 ions. The co-generated C2H3O neutrals are predicted to be vinyloxy radicals CH2CHO in admixture with CH3CO generated by quid-pro-quo (QPQ) catalysis. A competing C-C bond cleavage in FE1 leads to HBRC [CH2N(H)C(H)O-...H...OCH2] +, which serves as the direct precursor for CH2O loss. In addition, ion FE2 also communicates with a myriad of ion-molecule complexes of vinyl alcohol and formimidic acid whose components may recombine to form distonic ion FE3, HOCH(CH2)N(H)C(H)OH+, which loses H 2O after undergoing a 1,5-H shift. Further support for these proposals comes from experiments with D- and 18O-labelled isotopologues. Previously reported proposals for the H2O and CO losses from protonated N-formylethanolamine are briefly re-examined.

Toward the design of LPEI containing block copolymers: Improved synthesis protocol, selective hydrolysis, and detailed characterization

The synthesis of poly(2-ethyl-2-oxazoline)-b-linear poly(ethylenimine) (PEtOx-b-LPEI) copolymers by selective basic hydrolysis of PEtOx-b-poly(2-H-2- oxazoline) (PEtOx-b-PHOx) is described. For this purpose, an easy method for the preparation of the 2-H-2-oxazoline (HOx) monomer was developed. Based on the microwave-assisted polymerization kinetics for this monomer, PEtOx-b-PHOx copolymers were prepared. Subsequently, the block copolymers were selectively hydrolyzed to PEtOx-b-LPEI under basic conditions. The success of the polymerizations and subsequent post-polymerization reactions was demonstrated by 1H NMR spectroscopy and MALDI-TOF-MS investigations of the obtained polymers.

ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE

The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available dimethyl pyridazine-3,6-dicarboxylate building block. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.

METHOD OF MAKING UP WITH LIGHT-SENSITIVE MAKEUP BY APPLYING A BASE LAYER AND A KIT FOR IMPLEMENTING SUCH A METHOD

The present invention provides a method of making up human keratinous material with light-sensitive makeup, wherein: a) a base layer of a first composition is applied to the keratinous material, the first composition containing at least one optical agent that configured for, at least temporarily, of forming a screen at a wavelength λ; andb) a thermally stable photochromic second composition is applied on the base layer, the second composition being developable by exposure to a radiation at least of the wavelength λ.

METHOD OF MAKING UP WITH A LIGHT-SENSITIVE MAKEUP, AND A LIGHT-SENSITIVE MAKEUP COMPOSITION

The present invention provides a method of making up human keratinous material with a light-sensitive makeup, in which: i. a layer of a thermally stable photochromic composition comprising a photochromic agent capable of being developed by UV radiation and an optical agent that screens UV radiation is applied to the keratinous material; and ii. the layer of composition is exposed in non uniform manner to UV radiation to excite the photochromic agent and create a light-sensitive makeup look, the screening power F of the composition as regards solar UV radiation (280 nm to 400 nm) being 2 or more.

GLYCOPROTEIN SYNTHESIS AND REMODELING BY ENZYMATIC TRANSGLYCOSYLATION

A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (ENGase), to transfer the oligosaccharide moiety to the acceptor and yield the homogeneous glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of glycoprotein or glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody including a heterogeneous sugar chain, are also described. The disclosed methodology enables glycoprotein drugs to be modified for prolonged half-life in vivo, reduced immunogenicity, and enhanced in vivo activity, and for targeting and drug delivery.

Synthesis and catalytic properties of diverse chiral polyamines

Chiral polyamines can be utilized for a variety of potential applications, ranging from asymmetric catalysis to nonviral gene delivery systems for DNA and RNA. They can also be utilized to solubilize carbon nanotubes. Thus, methods for the straightforward synthesis of chiral polyamines are needed. We present herein two synthetic strategies for accessing chiral polyamines. The potential of these chiral amines to catalyze two organic reactions with a high degree of chiral induction was also explored.

Cosmetic composition forming a tackifying coating comprising a polymer with a non-silicone skeleton and reactive functional groups

Cosmetic compositions, comprising at least one polymer with a non-silicone skeleton, comprising at least two reactive chemical functional groups, that is capable of forming a tackifying coating on the hair, a cosmetic process comprising the application of the composition to the hair, and also its use for producing a tackifying coating on the hair.

Cosmetic composition forming a soft coating comprising a polymer having a non-silicone backbone and reactive functional groups

Nontacky cosmetic compositions, such as hair compositions, comprising at least one polymer having a non-silicone backbone, comprising at least two reactive chemical functional groups, capable of forming a soft coating on hair, a cosmetic process comprising the application of this composition to hair and its use for producing a soft coating on hair.

Cosmetic composition forming a rigid coat, comprising a polymer with a non-silicone skeleton and containing reactive functional groups

Cosmetic compositions, such as hair compositions, comprising at least one polymer with a non-silicone skeleton, comprising at least two reactive chemical functional groups, which are capable of forming a rigid coat on the hair, a cosmetic process comprising the application of this composition onto the hair, and its use for producing a rigid coat on the hair.