24599-38-0Relevant academic research and scientific papers
Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock
Kolarski, Du?an,Miller, Simon,Oshima, Tsuyoshi,Nagai, Yoshiko,Aoki, Yugo,Kobauri, Piermichele,Srivastava, Ashutosh,Sugiyama, Akiko,Amaike, Kazuma,Sato, Ayato,Tama, Florence,Szymanski, Wiktor,Feringa, Ben L.,Itami, Kenichiro,Hirota, Tsuyoshi
, p. 2078 - 2087 (2021)
CRY1 and CRY2 proteins are highly conserved components of the circadian clock that controls daily physiological rhythms. Disruption of CRY functions are related to many diseases, including circadian sleep phase disorder. Development of isoform-selective a
Preparation method of asymmetric azobenzene
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Paragraph 0045; 0049; 0054; 0058; 0063; 0067; 0071, (2018/11/03)
The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of asymmetric azobenzene. The preparation method of the asymmetric azobenzene comprises the step of carrying out ring-opening-oxidizing reaction on a
Correlation of Carbon-13 Substituent-Induced Chemical Shifts: meta- and para-Substituted Methyl Benzoates
Budesinsky, Milos,Exner, Otto
, p. 585 - 591 (2007/10/02)
Carbon-13 NMR spectra are reported for 69 substituted methyl benzoates in deuteriochloroform or in its mixture with dimethyl sulphoxide-d6.The substituent-induced chemical shifts (SCS) of the CO carbon correlate poorly with dual substituent parameters (DSP) in all possible modifications, and for meta derivatives in particular this correlation is both overparameterized and imprecise.A much better correlation was obtained with parameters (designated Bm, Bp and Cp) derived previously by principal component analysis (PCA) from a larger set.The SCS of the CH3 carbon correlate very well with the original simple Hammett equation, and no DSP treatment is needed.The clustering of substituents is not consequential in such a large set.KEY WORDS Methyl benzoates 13C NMR Substituent effects
The Electronic Effect of the Phenylazo and t-Butylazo Groups
Byrne, Christopher J.,Happer, Duncan A. R.,Hartshorn, Michael P.,Powell, H. Kipton J.
, p. 1649 - 1654 (2007/10/02)
Hammett ?p+-values for arylazo and t-butylazo groups have been determined by measurements of the kinetics of solvolysis of the appropriately substituted arylpropan-2-yl chlorides.They have been found to be considerably more positive than expected and differ significantly from earlier estimates based on the rates of electrophilic attack on azobenzene.An interpretation of the discrepancy has been advanced based on the differing orientations of the azo linkage with respect to the aromatic ring in the transition state.The introduction of methyl groups into positions ortho to the phenylazo and t-butylazo substituents causes a change in character from -I, -R to -I, +R.This is true not only for the solvolysis reaction but also for benzoic acid ionisation.
