24603-53-0

Basic information

• Product Name: 1,2-Benzisoxazol-3-ol, benzoate (ester)
• CAS NO: 24603-53-0
• Molecular Formula: C14H9NO3
• Molecular Weight: 239.23
• Mol File: 24603-53-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Benzisoxazol-3-ol, benzoate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisoxazol-3-ol, benzoate (ester)(24603-53-0)
• EPA Substance Registry System: 1,2-Benzisoxazol-3-ol, benzoate (ester)(24603-53-0)

Safety Data

• Hazardous Substances Data: 24603-53-0(Hazardous Substances Data)

Upstream product

• 94820-31-2 1,2-benzisoxazol-3-yl diphenyl phosphate 
• 65-85-0 benzoic acid 
• 88820-77-3 N,N'-carbonyldi<1,2-benzisoxazol-3(2H)-one> 
• 21725-69-9 3-hydroxybenzisoxazole 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

BENZISOXAZOLES

The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents an integer from 1 to 3; X represents amino, hydroxy, -oxo or -Z-R1; Y is absent when X represents -Z-R1 and -(C=O)-R66 when X represents oxo; Z represents carbonyl, -oxy-carbonyl- or -NR 55-carbonyl-; R1 represents C1-4alkyl, Ar1, Ar1-C1-4a1ky1-, -NR3R4 or -Het1; R2 represents hydrogen, halo, nitro, hydroxycarbonyl-, C1-4alkyloxy or C1-4alkyl; R33 and R4 are each independently selected from hydrogen, Ar33 or C1-4alkyl; R5 represents hydrogen, C1-4alkylcarbonyl- or Ar4-carbonyl-; R6 represents a substituent selected from the group consisting of C1.4alkyl, Ar55, Ar6-C1-4alkyl- or NR7R8; R7 and R8 are each independently selected from hydrogen, Het4 or C1-4alkyl; Het1 represents a heterocycle selected from oxazolyl, isoxazolyl, imidazolyl or pyrazolyl wherein said heterocycle is optionally substituted with one, two or three substituents selected from the group consisting of amino, C1-4alkyl, hydroxy-C1-4alkyl, phenyl, phenyl-C1-4alkyl- and phenyl substituted with one or more halo substituents; Het4 represents a heterocycle selected from oxazolyl or isoxazolyl, wherein said heterocycle is optionally substituted with one or more substituents selected from the group consisting of amino, C1-4alkyl, hydroxy-C1-4alkyl-, phenyl, phenyl-Cl-4alkyl and phenyl substituted with one or more halo substituents; and Ar1, Ar2, Ar3, Ar4, Ar5 or Ar6 each independently represents phenyl optionally substituted one or where possible two or more substituents selected from halo, nitro, C1-4alkyl, hydroxy or C1-4alkyloxy-.

1,2-BENZISOXAZOL-3(2H)-ONE.

A new condensing agent, N,N prime -carbonyldi left bracket 1,2-benzisoxazol-3(2H)-one right bracket (6), was readily prepared by the reaction of 1,2-benzisoxazol-3-ol and trichloromethyl chloroformate in toluene. The condensing agent 6 was shown to be very useful for the preparation of amides, esters, and dipeptides under mild conditions. A successful polyamide synthesis by one-pot polycondensation of isophthalic acid with diamines using 6 is also described.