246237-51-4Relevant academic research and scientific papers
Discovery and structure-activity relationships of a novel series of benzopyran-based KATP openers for urge urinary incontinence
Zhang, Xuqing,Qiu, Yuhong,Li, Xiaojie,Bhattacharjee, Sheela,Woods, Morgan,Kraft, Patricia,Lundeen, Scott G.,Sui, Zhihua
scheme or table, p. 855 - 866 (2009/09/06)
A novel series of benzopyran derivatives were synthesized and evaluated as KATP channel openers. Structure-activity relationships were investigated around 4-position of the benzopyran nucleus. Optimization of 4-substituent with some heterocyclic rings led to compound 13b bearing a benzo[d]isoxazol-3-one moiety as a potent and selective KATP channel opener in vitro. In two anesthetized rat models of myogenic bladder overactivity, compound 13b was found to inhibit spontaneous bladder contractions.
Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines
Ding, Charles Z.,Rovnyak, George C.,Misra, Raj N.,Grover, Gary J.,Miller, Arthur V.,Ahmed, Syed Z.,Kelly, Yolanda,Normandin, Diane E.,Sleph, Paul G.,Atwal, Karnail S.
, p. 3711 - 3717 (2007/10/03)
The effect on potency and selectivity of modification at the C6 position of the cardioprotective K(ATP) opener BMS-180448 (2) is described. Structure- activity studies show that a variety of electron-withdrawing groups (ketone, sulfone, sulfonamide, etc.)
