91735-45-4

Upstream product

• 78-79-5 isoprene 
• 1137-42-4 4-Hydroxybenzophenone 
• 118585-39-0 [4-(2-methylbut-3-yn-2-yloxy)phenyl](phenyl)methanone 
• 93-89-0 benzoic acid ethyl ester 
• 151071-00-0 4-bromo-2-(3-methylbut-2-en-1-yl)phenol 
• 63565-09-3 6-benzoyl-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran 

Downstream Products

• 927413-09-0 (S,S)-(2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalen-6-yl)-phenyl-methanone 
• 246237-51-4 ((3S,4R)-4-Amino-3-hydroxy-2,2-dimethyl-chroman-6-yl)-phenyl-methanone 
• 246237-52-5 (3S-trans)-4-amino-3,4-dihydro-2,2-dimethyl-6-(1-phenylethenyl)-2H-1-benzopyran-3-ol 

Relevant academic research and scientific papers

Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues

We recently reported that 3,3-dimethyl-3H-benzofuro[3,2,f][1]-benzopyran and its hydrogenated analogue are selective in vitro inhibitors of mycobacterial growth. However, their lack of in vivo activity on a murine model of Mycobacterium tuberculosis infec

Selenium-based solid-phase synthesis of benzopyrans II: Applications to combinatorial synthesis of medicinally relevant small organic molecules

The transfer-hydrogenation of ketones with iPrOH in the presence of a base is catalyzed by pincer-aryl ruthenium(II) complexes (see scheme, R3 = NMe2 or PPh2, X = Cl or OSO2CF3). Conversions of 90-98% are achieved without removal of the acetone by-product. The structural unit [Ru(pincer- aryl)PPh3] is stable under the reaction conditions and is preserved during the catalytic cycle. An anionic Ru(II) hydrido complex was identified as the resting state of the catalyst at the onset of the reaction.

An Improved Synthesis of Benzoyl-chromans and Chromenes

Direct nuclear isoprenylation of polyhydroxybenzophenones with 2-methylbut-1,3-diene (isoprene) in the presence of orthophosphoric acid results exclusively in the formation of benzoylchromans in good yields.These benzoylchromans on dehydrogenation with DD