246237-52-5Relevant academic research and scientific papers
Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines
Ding, Charles Z.,Rovnyak, George C.,Misra, Raj N.,Grover, Gary J.,Miller, Arthur V.,Ahmed, Syed Z.,Kelly, Yolanda,Normandin, Diane E.,Sleph, Paul G.,Atwal, Karnail S.
, p. 3711 - 3717 (2007/10/03)
The effect on potency and selectivity of modification at the C6 position of the cardioprotective K(ATP) opener BMS-180448 (2) is described. Structure- activity studies show that a variety of electron-withdrawing groups (ketone, sulfone, sulfonamide, etc.)
