24624-78-0Relevant articles and documents
Propargyl-containing xylose and synthesis method thereof
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, (2020/07/28)
The invention discloses propargyl-containing xylose and a preparation method thereof. The method comprises the following steps: using D-xylose as a raw material, carrying out full acetyl protection onthe D-xylose, introducing p-nitrophenoxy into a first position of an obtained compound, and removing acetyl to obtain a compound A; introducing tert-butyl dimethyl into the position 2, the position 3or the position 4 of the obtained compound A to obtain a compound B, a compound C and a compound D, and separating the compound B, the compound C and the compound D; and respectively carrying out acetyl protection on hydroxyl groups of the compound B, the compound C and the compound D, then removing the tert-butyl dimethyl, and respectively introducing propargyl into the position 2, the position3 and the position 4 to obtain the propargyl-containing xylose. According to the method disclosed by the invention, the propargyl is selectively connected to xylose for the first time by using a method for carrying out occupying by using tert-butyl dimethyl (TBS), so that a platform is provided for subsequent connection of the xylose to protein or amino acid, and a foundation is laid for biological research in the future.
Synthesis and inhibitory activity evaluation of 2,6-disubstituted purine derivatives
Liu, Hongxia,Li, Libo,Qurat-Ul-Ain, Shaikh,Jiang, Tao
, p. 473 - 477 (2015/03/30)
A series of novel 2,6-disubstituted purine derivatives were designed and synthesized from 2,6-dichloropurine. The structures of target compounds were determined by 1H-NMR, 13C-NMR, and HRMS. The synthesized compounds were evaluated for their inhibitory activities against lung cancer cell lines of A549 and liver cancer cell lines of Bel-7402. 2-(4-Benzyloxy-phenylamino)-6-(cyclohexylamino)purine(3), 2-(4-chloro-phenylamino)-6-(n-butylamino)purine (5), 2-(4-morpholinoamino)-6-(4-hydroxy-phenylamino)purine (9), and 2-(4-O-galactosyl-phenylamino)-6-(cyclohexylamino)purine (12) exhibited moderate inhibitory activity.
Glycosynthase-Mediated Assembly of Xylanase Substrates and Inhibitors
Goddard-Borger, Ethan D.,Fiege, Brigitte,Kwan, Emily M.,Withers, Stephen G.
experimental part, p. 1703 - 1711 (2012/06/29)
An exo-β-xylosidase mutant with glycosynthase activity was created to aid in the synthesis of xylanase substrates and inhibitors. Simple monosaccharides were easily elaborated into di-, tri- and tetrasaccharides by using this enzyme. Some products proved