2466-87-7

Basic information

• Product Name: Z-L-Tyr-L-Val-OMe
• Synonyms: Z-L-Tyr-L-Val-OMe
• CAS NO: 2466-87-7
• Molecular Weight: 428.485
• Mol File: 2466-87-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Z-L-Tyr-L-Val-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: Z-L-Tyr-L-Val-OMe(2466-87-7)
• EPA Substance Registry System: Z-L-Tyr-L-Val-OMe(2466-87-7)

Safety Data

• Hazardous Substances Data: 2466-87-7(Hazardous Substances Data)

Upstream product

• 4070-48-8 L-Valine methyl ester 
• 13512-31-7 N-(benzyloxycarbonyl)-L-tyrosine methyl ester 
• 5618-98-4 N-α-benzyloxycarbonyl-DL-tyrosine 
• 6306-52-1 L-valine methylester hydrochloride 
• 72-18-4 L-valine 
• 1164-16-5 Z-L-Tyr-OH 
• 501-53-1 benzyl chloroformate 
• 3417-91-2 L-tyrosine methyl ester HCl 

Relevant articles and documents

Enzyme-Catalyzed Irreversible Formation of Peptides Containing D-Amino Acids

Procedures have been developed for the preparation of dipeptides Z-L-Tyr-D-X and Z-L-Phe-D-X using Z-L-Tyr-OMe (or Z-L-Phe-OMe) and D-amino acid esters or amides (D-X) as substrates and soluble or immobilized α-chymotrypsin as a catalyst.The formation of each of these peptides in miscible or immiscible organic solvent-water systems in a kinetically controlled approach is virtually irreversible with no side reactions or racemization.Kinetic studies indicate that D-amino acid esters are about 100 times that of water and 10percent that of L-amino acid esters as a nucleophile in deacylation reactions.The effects of pH, organic solvents, temperature, and substrate and enzyme concentrations on the yield and the stability of the enzyme in syntheses have been studied and the results compared with those in the enzyme-catalyzed formation of L-L-dipeptides.

Enzyme-catalysed Synthesis of Peptides containing D-Amino Acids

Practical procedures are described for the preparation of D-amino acid-containing dipeptides using α-chymotrypsin and the Met(O)192-modified enzyme as a catalyst.