24689-28-9

Upstream product

• 2555-30-8 7-hydroxy-4-phenylcoumarin 
• 106-89-8 epichlorohydrin 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 108-46-3 recorcinol 

Downstream Products

• 125733-56-4 7-[2-hydroxy-3-(piperidin-1-yl)propoxy]-4-phenyl-2H-1-benzopyran-2-one 
• 757907-38-3 7-[2-hydroxy-3-(morpholin-4-yl)propoxy]-4-phenyl-2H-1-benzopyran-2-one 
• 1082467-70-6 7-[2-hydroxy-3-(piperazin-1-yl)propoxy]-4-phenyl-2H-1-benzopyran-2-one 
• 1082467-71-7 7-[2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy]-4-phenyl-2H-1-benzopyran-2-one 
• 125733-54-2 7-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]-4-phenyl-2H-1-benzopyran-2-one 
• 1082467-74-0 7-[2-hydroxy-3-(4-(2-chlorophenyl)piperazin-1-yl)propoxy]-4-phenyl-2H-1-benzopyran-2-one 
• 1082467-76-2 7-[2-hydroxy-3-(4-(2-methoxyphenyl)piperazin-1-yl)propoxy]-4-phenyl-2H-1-benzopyran-2-one 
• 1082467-69-3 7-[3-(diethylamino)-2-hydroxypropoxy]-4-phenyl-2H-1-benzopyran-2-one 
• 1082467-66-0 7-[3-butylamino-2-hydroxypropoxy]-4-phenyl-2H-1-benzopyran-2-one 
• 1338325-74-8 7-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)-2-hydroxypropoxy)-4-phenyl-2H-chromen-2-one 

Relevant academic research and scientific papers

BENZOPYRONE DERIVATIVE AND USE THEREOF

The present invention relates to the field of pharmaceutical chemistry, and in particular, to a benzopyrone derivative and a use thereof. The benzopyrone derivative is compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof. It has been found by experiments that, this type of compounds is useful in prevention or treatment of neuropsychical diseases.

BENZOPYRONE DERIVATIVE AND USE THEREOF

The present invention relates to the field of pharmaceutical chemistry, and in particular, to a benzopyrone derivative and a use thereof. The benzopyrone derivative is compound having a structure of formula (I) or a pharmaceutically acceptable salt thereof. It has been found by experiments that, this type of compounds is useful in prevention or treatment of neuropsychical diseases.

Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics

The discovery and synthesis of potential and novel antipsychotic coumarin derivatives, associated with potent dopamine D2, D3, and serotonin 5-HT1A and 5-HT2A receptor properties, are the focus of the present article. The most-promising derivative was 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)-piperidin-1-yl)butoxy) -4-methyl-8-chloro-2H-chromen-2-one (17m). This derivative possesses unique pharmacological features, including high affinity for dopamine D2 and D3 and serotonin 5-HT1A and 5-HT2A receptors. Moreover, it possesses low affinity for 5-HT2C and H1 receptors (to reduce the risk of obesity associated with chronic treatment) and hERG channels (to reduce the incidence of torsade des pointes). In animal models, compound 17m inhibited apomorphine-induced climbing behavior, MK-801-induced hyperactivity, and the conditioned avoidance response without observable catalepsy at the highest dose tested. Further, fewer preclinical adverse events were noted with 17m compared with risperidone in assays that measured prolactin secretion and weight gain. Acceptable pharmacokinetic properties were also noted with 17m. Taken together, 17m may constitute a novel class of drugs for the treatment of schizophrenia.

Design, synthesis, and docking studies of novel benzopyrone derivatives as H1-antihistaminic agents

Two new series of 2H-1-benzopyran-2-one derivatives substituted at C-6 and/or C-7 with propanolamines, and/or piperazine propanol derivatives have been synthesized and assayed for the H1-histamine antagonist. Twelve of the 20 newly synthesized