247025-11-2

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 247025-10-1 3-Azido-3-deoxy-4-C-hydroxymethyl-1,2-O-isopropylidene-α-D-erythro-pentofuranose 
• 153915-02-7 C₂₄H₂₃F₃O₁₀S 
• 230631-15-9 5-O-Benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-1,2-O-isopropylidene-β-L-threo-pentofuranose 
• 908142-25-6 1-2 O-isopropylidene 3-O-benzyl α(D)gluco-pentoaldofuranose 
• 591727-19-4 1-2,5-6 di-O-isopropylidene 3-O-benzyl α(D)gluco-pentoaldofuranose 
• 153914-98-8 3-Azido-5-O-benzoyl-4-C-benzoyloxymethyl-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 

Downstream Products

• 314297-18-2 (2aS,2bR,5aR,6aS)-6a-(tert-Butyl-diphenyl-silanyloxymethyl)-4,4-dimethyl-hexahydro-3,5,6-trioxa-2-aza-cyclobuta[a]pentalene 
• 314297-15-9 [(3aR,5R,6S,6aR)-6-Amino-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-methanol 
• 247025-12-3 3'-azido-5'-O-tert-butyldiphenylsilyl-3'-deoxy-4'-p-toluenesulfonyloxymethyl-1',2'-O-isopropylidene-α-D-ribofuranose 
• 247025-16-7 3'-azido-5'-O-tert-butyldiphenylsilyl-3'-deoxy-2'-O,4'-C-methylene-5-methyluridine 
• 314297-16-0 Toluene-4-sulfonic acid (3aR,5S,6S,6aR)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-6-(toluene-4-sulfonylamino)-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester 
• 314297-02-4 Acetic acid (1S,3R,4R,5S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6-(2,2,2-trifluoro-acetyl)-2-oxa-6-aza-bicyclo[3.2.0]hept-4-yl ester 
• 314297-22-8 (1S,4R,5S)-3,4-Diacetoxy-1-(tert-butyl-diphenyl-silanyloxymethyl)-2-oxa-6-aza-bicyclo[3.2.0]heptane-6-carboxylic acid benzyl ester 
• 314297-21-7 Acetic acid (1S,4R,5S)-3-acetoxy-1-(tert-butyl-diphenyl-silanyloxymethyl)-6-(2,2,2-trifluoro-acetyl)-2-oxa-6-aza-bicyclo[3.2.0]hept-4-yl ester 
• 314297-17-1 (2aS,2bR,5aR,6aS)-6a-(tert-Butyl-diphenyl-silanyloxymethyl)-4,4-dimethyl-2-(toluene-4-sulfonyl)-hexahydro-3,5,6-trioxa-2-aza-cyclobuta[a]pentalene 
• 314297-20-6 (2aS,2bR,5aR,6aS)-6a-(tert-Butyl-diphenyl-silanyloxymethyl)-4,4-dimethyl-tetrahydro-3,5,6-trioxa-2-aza-cyclobuta[a]pentalene-2-carboxylic acid benzyl ester 
• 314297-19-3 1-[(2aS,2bR,5aR,6aS)-6a-(tert-Butyl-diphenyl-silanyloxymethyl)-4,4-dimethyl-tetrahydro-3,5,6-trioxa-2-aza-cyclobuta[a]pentalen-2-yl]-2,2,2-trifluoro-ethanone 

Relevant academic research and scientific papers

MODIFIED NUCLEOSIDE PHOSPHORAMIDITES

The present disclosure relates to compounds and compositions containing 5'-phosphoramidite nucleoside monomers of formulae (I) and (II), and methods of making and use, wherein the substituents are as defined in the appended claims.

Synthesis and properties of 3′-amino-2′,4′-BNA, a bridged nucleic acid with a N3′→P5′ phosphoramidate linkage

The synthesis and properties of a bridged nucleic acid analogue containing a N3′→P5′ phosphoramidate linkage, 3′-amino-2′,4′-BNA, is described. A heterodimer containing a 3′-amino-2′,4′-BNA thymine monomer, and thymine and methylcytosine monomers of 3′-am

Synthesis of a conformationally locked AZT analogue, 3'-azido-3'-deoxy- 2'-O,4'-C-methylene-5-methyluridine

A bicyclic 3'-azido-3'-deoxythymidine (AZT) analogue with a locked N- conformation, 3'-azido-3'-deoxy-2'-O,4'-C-methylene-5-methyluridine (1a), and its 3'-amino derivative, 3'-amino-3'-deoxy-2'-O,4'-C-methylene-5- methyluridine (1b), were successfully synthesized from D-glucose. The conformation of 1a was also discussed by means of 1H NMR measurements and a molecular modeling (PM3) study.