247069-27-8

Basic information

• Product Name: 3,5-Difluoropyridine-2,6-diamine
• Synonyms: 2,6-DIAMINO-3,5-DIFLUOROPYRIDINE;3,5-DIFLUOROPYRIDINE-2,6-DIAMINE;2,6-Pyridinediamine, 3,5-difluoro- (9CI);3,5-Difluoropyiridine;2,6-Diamino-3,5-difluoropyridi;3,5-difluoro-2,6-PyridinediaMine;2,6-PyridinediaMine, 3,5-difluoro-
• CAS NO: 247069-27-8
• Molecular Formula: C₅H₅F₂N₃
• Molecular Weight: 145.11
• EINECS: 1312995-182-4
• Product Categories: AMINEPRIMARY;HALIDE;PYRIDINE;Amines;Pyridines;Heterocycle;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Building Blocks;C5;C5 to C6;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Fluorine series;Furans
• Mol File: 247069-27-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 160°C
• Boiling Point: 233.265 °C at 760 mmHg
• Flash Point: 94.876 °C
• Appearance: /
• Density: 1.517 g/cm³
• Vapor Pressure: 0.056mmHg at 25°C
• Refractive Index: 1.602
• PKA: 1.93±0.10(Predicted)
• CAS DataBase Reference: 3,5-Difluoropyridine-2,6-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluoropyridine-2,6-diamine(247069-27-8)
• EPA Substance Registry System: 3,5-Difluoropyridine-2,6-diamine(247069-27-8)

Safety Data

• Hazard Codes: Xi,T
• Statements: 21/22-36/37-36
• Safety Statements: 24-26-36/37/39
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 247069-27-8(Hazardous Substances Data)

Usage

Physical properties

3,5-Difluoropyridine-2,6-diamine is soluble in water (slightly).

Uses

3,5-Difluoropyridine-2,6-diamine is a reagent used for the synthesis of 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone which is possessed antimycobacterial and antibacterial activity.

InChI:InChI=1/C5H5F2N3/c6-2-1-3(7)5(9)10-4(2)8/h1H,(H4,8,9,10)

Upstream product

• 2875-18-5 2,3,5,6-tetrafluoropyridine 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 247069-28-9 N₂,N₆-dibenzyl-2,6-diamino-3,5-difluoropyridine 

Downstream Products

• 875712-88-2 (E)-1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 875712-88-2 (Z)-1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 442526-91-2 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 
• 875712-88-2 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Direct di- and triamination of polyfluoropyridines in anhydrous ammonia

Aminodefluorination of polyfluoropyridines (pentafluoro-, 3,5-dichlorotrifluoro-, 3- and 4-chlorotetrafluoro-, 2,3,5,6- and 2,3,4,6-tetrafluoro-, 3-chloro-2,4,6-trifluoro-, and 2,4,6-trifluoropyridine) in anhydrous ammonia has been investigated. Temperatu

Preparation method of 3,5-difluoro-2,6-diaminopyridine

The invention discloses a preparation method of 3,5-difluoro-2,6-diaminopyridine, and belongs to the technical field of preparation methods of chemical drug intermediates. 2,3,4,5,6-pentachloropyridine is utilized as a raw material; and the 3,5-difluoro-2,6-diaminopyridine is prepared through reduction by a metallic reducing agent, fluorination and aminolysis. The method provided by the inventionis simple to operate, short in reaction time, environmentally friendly in process route and higher in yield, and has higher industrialization value; and an economical and high-efficiency catalyst is adopted.

PREPARATION OF PYRIDONECARBOXYLIC ACID ANTIBACTERIALS

A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.