247142-68-3

Upstream product

• 4767-03-7 2,2-bis(hydroxymethyl)propionic acid 
• 100-39-0 benzyl bromide 
• 124-38-9 carbon dioxide 
• 179388-73-9 benzyl 2,2-bis(hydroxylmethyl)propionate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 100-44-7 benzyl chloride 
• 201230-82-2 carbon monoxide 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1252553-69-7 pentafluorophenyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate 
• 100-51-6 benzyl alcohol 
• 59483-84-0 bis(pentafluorophenyl)carbonate 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 507471-78-5 5-methyl-2-oxo-[1,3]dioxane-5-carboxylic acid 
• 532424-75-2 allyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate 
• 1240326-67-3 C₁₅H₁₈N₂O₆ 

Relevant academic research and scientific papers

Synthesis of 6-membered cyclic carbonates from 1,3-diols and low CO2 pressure: A novel mild strategy to replace phosgene reagents

Low pressure carbon dioxide is used as the carbonation agent in a simple, safe and efficient procedure for the synthesis of 6-membered cyclic carbonates from 1,3-diols. Using readily available reagents and proceeding at room temperature, this route offers a novel mild alternative to phosgene derivatives.

ApoE mimetic peptide targeted nanoparticles carrying a BRD4 inhibitor for treating Medulloblastoma in mice

Treatment of medulloblastoma (MB) is challenging due to diverse genetic make-up, chemoresistance and inefficient drug transport across the blood brain barrier (BBB). Since hedgehog (Hh) signaling regulates cancer cell proliferation and tumorigenicity, Hh

Immuno-polymeric nanoparticles by Diels-Alder chemistry

(Figure Presented) Hitting the target: Self-assembled polymeric nanoparticles from an amphiphilic copolymer were prepared with furan groups on the outer polyethylene glycol corona that were accessible for Diels-Alder reactions with maleimide-functionalize

Overcoming Barriers in Polycarbonate Synthesis: A Streamlined Approach for the Synthesis of Cyclic Carbonate Monomers

Accessing cyclic carbonate monomers on a large scale is critical for the development of any new carbonate-based materials platform. The synthesis of carbonate monomers can be a challenging and tedious endeavor requiring multiple synthetic steps and purifications. To address this, we report a drastically improved process for the synthesis of carbonate monomers via a two-step route that avoids the use of hazardous triphosgene or chloroformate reagents. This process enables rapid access to a broad array of functional groups on the carbonate monomer and the monomers generated from the procedure can readily be polymerized via ring-opening polymerization.

Degradation behavior of poly(lactide-co-carbonate)s controlled by chain sequences

Immortal copolymerization of lactide (LA) and 2-methyl-2-benzyloxycarbonyl-1,3-trimethylene carbonate (MBC) affords random, tapered, and diblock microstructured poly(lactide-co-carbonate)s. Subsequent debenzylation of these poly(LA-co- MBC)s by Pd/C catalytic hydrogenation gives poly(LA-co-MCC)s containing carboxylic acid, which show controlled degradation performance during in vitro hydrolytic degradation experiments. The degradation rates of poly(LA-co-MCC)s are proved for the first time to be affected significantly by lactide-carbonate linkages in the main chains, following the trend of lactide-carbonate unit (L- C/C-L)>carbonate-carbonate unit (C-C)>lactide-lactide unit (L-L). The resultant hydrolysis products are the precursors for synthesizing the corresponding monomers. Therefore, the degradable and recyclable materials are accomplished.

Nanoparticulate delivery of potent microtubule inhibitor for metastatic melanoma treatment

Melanoma is the most aggressive type of skin cancer, which readily metastasizes through lymph nodes to the lungs, liver, and brain. Since the repeated administration of most chemotherapeutic drugs develops chemoresistance and severe systemic toxicities, h

Highly Stable, Coordinated Polymeric Nanoparticles Loading Copper(II) Diethyldithiocarbamate for Combinational Chemo/Chemodynamic Therapy of Cancer

Disulfiram (DSF) has excellent in vitro anticancer activity in the presence of Cu(II). The anticancer mechanism studies have demonstrated that copper(II) diethyldithiocarbamate, Cu(DDC)2, is the crucial DSF's metabolite exhibiting anticancer ac

Cholesterol and Morpholine Grafted Cationic Amphiphilic Copolymers for miRNA-34a Delivery

miR-34a is a master tumor suppressor playing a key role in the several signaling mechanisms involved in cancer. However, its delivery to the cancer cells is the bottleneck in its clinical translation. Herein we report cationic amphiphilic copolymers graft

Synthesis and liquid crystal behavior of new side chain aliphatic polycarbonates based on cholesterol

In this study, we synthesized a series of new liquid crystal aliphatic block polycarbonates copolymers mPEG43-b-P(MCC-Cn)51 (n = 1–4) via the ring-opening polymerization, hydrogenation reduction and coupling reaction, which contained side functionalized cholesteryl groups and were different in the number of the flexible methylene groups. The chemical structures of the chiral compounds and copolymers obtained in this study were characterized by FT-IR and 1H NMR spectra, and the average molecular weights of the copolymers were investigated by average molecular weights gel permeation chromatographic (GPC). The polarizing optical microscopy (POM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to characterize the liquid crystal behavior. The relationship of the structure and phase behavior of the chiral compounds and copolymers influenced by spacer lengths was discussed. As a result, the chiral compounds with two methylene only showed a smectic A (SmA) phase, while those with more methylene showed a SmA phase and cholesteric phase. As the number of the flexible methylene groups increased, the corresponding melting temperature, the transition temperatures of LC phases and the isotropic temperature of chiral compounds all showed a decreasing trend, and mesophase temperature range narrowed. The polycarbonate copolymer with two methylene did not show mesomorphism, while the copolymers with longer spacer length seemed beneficial for the formation of mesophases at room temperature and revealed a smectic A phase with an interdigitated molecular arrangement on heating and cooling cycles. The results showed a decreased tendency toward the glass temperature, and an increased tendency toward isotropic temperature for the LC copolymers with an increase of the spacer length.

2-methyl-2-(5-fluorouracil)carbonyltrimethylene carbonate as well as preparation method and application thereof

The invention provides a monomer material 2-methyl-2-(5-fluorouracil)carbonyltrimethylene carbonate which can be used for synthesizing biodegradable polycarbonate, wherein the 2-methyl-2-(5-fluorouracil)carbonyltrimethylene carbonate is a white crystal, t