247170-98-5

Upstream product

• 501-53-1 benzyl chloroformate 
• 179167-09-0 N,N-bis(2-aminoethyl)-N-[2-(N-t-butoxycarbonylamino)ethyl]amine 
• 247170-99-6 dibenzyl {[(2-aminoethyl)azanediyl]bis(ethane-2,1-diyl)}dicarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4097-89-6 2,2',2''-triaminotriethylamine 
• 3422-02-4 N-(benzyloxycarbonyl)aniline 

Downstream Products

• 247170-99-6 dibenzyl {[(2-aminoethyl)azanediyl]bis(ethane-2,1-diyl)}dicarbamate 

Relevant academic research and scientific papers

MACROCYCLES

The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.

A macrocyclic chelator with unprecedented Th4+ affinity

A novel macrocyclic octadentate ligand incorporating terephthalamide binding units has been synthesized and evaluated for the chelation of Th 4+. The thorium complex was structurally characterized by X-ray diffraction and in solution with kinetic studies and spectrophotometric titrations. Dye displacement kinetic studies show that the ligand is a much more rapid chelator of Th4+ than prevailing ligands (1,4,7,10- tetraazacyclododecane-1,4,7,10-tetraacetic acid and diethylenetriaminepentaacetic acid). Furthermore, the resulting complex was found to have a remarkably high thermodynamic stability, with a formation constant of 1054. These data support potential radiotherapeutic applications.

SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS

The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.