247172-13-0Relevant academic research and scientific papers
Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins
Medarde, Manuel,Ramos, Angel C.,Caballero, Esther,Pelaez-Lamamie de Clairac, Rafael,Lopez, Jose Luis,Gravalos, Dolores G.,San Feliciano, Arturo
, p. 2303 - 2308 (1999)
Taking into account the structure of Combretastatins, we have synthesized and assayed for cytotoxic activity of new indole derivatives. Two aryl groups are maintained in the cis orientation required for activity by means of an indole moiety built up on le
New naphthylcombretastatins. Modifications on the ethylene bridge
Sanchez Maya, Ana B.,Perez-Melero, Concepcion,Salvador, Nelida,Pelaez, Rafael,Caballero, Esther,Medarde, Manuel
, p. 2097 - 2107 (2007/10/03)
Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with t
