Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins

DOI: 10.1016/S0960-894X(99)00370-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2303 - 2308 (1999)

Update date:2022-08-11

Topics:

Authors:

Medarde, Manuel

Ramos, Angel C.

Caballero, Esther

Pelaez-Lamamie de Clairac, Rafael

Lopez, Jose Luis

Gravalos, Dolores G.

San Feliciano, Arturo

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Article abstract of DOI:10.1016/S0960-894X(99)00370-4

Taking into account the structure of Combretastatins, we have synthesized and assayed for cytotoxic activity of new indole derivatives. Two aryl groups are maintained in the cis orientation required for activity by means of an indole moiety built up on le

Full text of DOI:10.1016/S0960-894X(99)00370-4

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