247196-65-2

Basic information

• Product Name: 2-(4-chloro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole
• Synonyms: 2-(4-chloro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole
• CAS NO: 247196-65-2
• Molecular Weight: 221.686
• Mol File: 247196-65-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-chloro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chloro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole(247196-65-2)
• EPA Substance Registry System: 2-(4-chloro-phenyl)-4,4-dimethyl-5-methylene-4,5-dihydrooxazole(247196-65-2)

Safety Data

• Hazardous Substances Data: 247196-65-2(Hazardous Substances Data)

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 24911-15-7 4-chloro-N-(1,1-dimethylprop-2-ynyl)benzamide 
• 123-86-4 acetic acid butyl ester 

Relevant articles and documents

CuI-catalyzed cycloisomerization of propargyl amides

The synthesis of substituted dihydrooxazoles by the CuI-catalyzed cycloisomerization of terminal propargyl amides is reported. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Substrates containing a benzylic methylene were oxidized to the ketone under the reaction conditions.

Metal salt catalyzed process to oxazolines and subsequent formation of chloroketones

This invention relates to a process for the preparation of an α-chloroketone compound comprising the steps of (i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene, R is a hydrogen atom or alkyl, and R1and R2are each independently an alkyl or substituted alkyl group, or R1and R2together with the carbon atom to which they are attached form a cyclic structure. Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.