247236-78-8Relevant academic research and scientific papers
Novel peptoid building blocks: Synthesis of functionalized aromatic helix-inducing submonomers
Seo, Jiwon,Barron, Annelise E.,Zuckermann, Ronald N.
supporting information; experimental part, p. 492 - 495 (2010/05/02)
[Chemical equation presented] Peptoids, oligo-N-substituted glycines, can fold into well-defined helical secondary structures. The design and synthesis of new peptoid building blocks that are capable of both (a) inducing a helical secondary structure and
Reversal of diastereofacial selectivity in hydride reductions of N-tert-butanesulfinyl imines
Colyer, John T.,Andersen, Neil G.,Tedrow, Jason S.,Soukup, Troy S.,Faul, Margaret M.
, p. 6859 - 6862 (2007/10/03)
A variety of N-tert-butanesulfinyl imines were reduced with NaBH 4 in THF containing 2% water to provide the corresponding secondary sulfinamides in high yield and diastereoselectivity. By using the same sulfinyl imine starting materials and changing the reductant to L-Selectride, the stereoselectivity could be efficiently reversed to afford the opposite product diastereomer in high yield and selectivity.
One-pot asymmetric synthesis of tert-butanesulfinyl-protected amines from ketones by the in situ reduction of tert-butanesulfinyl ketimines
Borg, George,Cogan, Derek A.,Ellman, Jonathan A.
, p. 6709 - 6712 (2007/10/03)
A one-pot method for the asymmetric synthesis of tert-butanesulfinyl-protected amines is described. The ketones 2 are condensed with (R)-tert-butanesulfinamide 1 and the tert-butanesulfinyl imine intermediates reduced in situ with NaBH4 to affo
