24751-69-7

Usage

Uses

Nucleocidin is used in studies relating to novel parasite inhibitors.

InChI:InChI=1/C10H13FN6O6S/c11-10(1-22-24(13,20)21)6(19)5(18)9(23-10)17-3-16-4-7(12)14-2-15-8(4)17/h2-3,5-6,9,18-19H,1H2,(H2,12,14,15)(H2,13,20,21)/t5-,6+,9-,10-/m1/s1

Upstream product

• 151725-74-5 5'-deoxy-4'-fluoro-5'-iodo-2',3'-O-isopropylideneadenosine 
• 39947-04-1 N-6-benzoyl-2',3'-O-isopropylideneadenosine 
• 362-75-4 2',3'-isopropylidene adenosine 
• 59996-37-1 N⁶,N⁶-dibenzoyl-5'-deoxy-4'-fluoro-5'-iodo-2',3'-O-isopropylideneadenosine 
• 40653-96-1 N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-methylsulfonyladenosine 
• 33962-34-4 5'-azido-5'-deoxy-4'-fluoro-2',3'-O-isopropylideneadenosine 
• 33962-29-7 N-(9-((3aR,4R,6aS)-2,2-dimethyl-6-methylenetetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)benzamide 
• 59996-36-0 N⁶,N⁶-dibenzoyl-9-(5-deoxy-2,3-O-isopropylidene-β-D-erythropent-4-enofuranosyl)adenine 
• 33982-04-6 4'-fluoro-2',3'-O-isopropylideneadenosine 

Relevant academic research and scientific papers

Two 3′-: O-β-glucosylated nucleoside fluorometabolites related to nucleocidin in Streptomyces calvus

The antibiotic nucleocidin is a product of the soil bacterium Streptomyces calvus T-3018. It is among the very rare fluorine containing natural products but is distinct from the other fluorometabolites in that it is not biosynthesised from 5′-fluorodeoxya

Synthetic Approaches towards Nucleocidin and Selected Analogues; anti-HIV Activity in 4'-Fluorinated Nucleoside Derivatives

Nucleocidin 1 has been synthesised from the adenosine derivative 4 via the intermediacy of the dihalogeno compound 9.The latter compound showed slight but significant activity against HIV-infected cells while the isomer 10 and the monohalogeno compound 60 were inactive.Synthetic approaches towards other 4'-fluorinated nucleoside derivatives are also described.The epimeric 4'-fluorinated nucleosides 26 and 27 displayed similar activity against HIV-infected cells to that observed for the dihalogenated compound 9.