220031-94-7Relevant articles and documents
2-ALKOXY-6-AMINO-5-HALOGENO-N-(1-SUBSTITUTED-4-PIPERIDINYL)PYRIDINE-3-CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
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Page/Page column 23, (2010/02/11)
PROBLEM TO BE SOLVED: To provide a compound exhibiting high affinity for serotonin 4 receptor and useful as a digestive tract motion promoting agent or digestive tract function ameliorating agent. SOLUTION: The compound is represented by the formula(I), or an acid addition salt thereof and an intermediate thereof are provided. In formula(I), R1 is a halogen atom; R2 is H or a lower alkyl; R3 is H, a lower alkyl or the like; R4 is a lower alkyl; A is a group represented by the formula: Z-N(Q1)(Q2) or CO-R5, wherein Z is CO, CS or the like; Q1 and Q2 are each H, a lower alkyl or the like, or joined together with the nitrogen atom to which Q1 and Q2 are bound to form a pyrrolidine ring, piperidine ring or the like; and R5 is H, a lower alkyl, lower alkoxy, lower alkoxycarbonyl or the like.
1-[(1-Substituted-4-piperidinyl)methyl]-4-piperidine derivative, process for producing the same, medicinal compositions containing the same and intermediates of these compounds
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, (2008/06/13)
Compound of the formula (I): STR1wherein Ar is a group of the following formula (Ar-1) or (Ar-2): STR2A is a group of the formula:--Z--N(Q 1)(Q 2), --CO--R 7or--(CH 2)p--CH(R 8)--COR 9,or a pharmaceutically acceptable acid addition salt thereof, a process for preparing the same, a pharmaceutical composition containing the same, and intermediates therefor. The compounds of the present invention show a potent affinity for 5-HT 4 receptors, and they are useful as a gastrointestinal motility enhancer or a gastrointestinal prokinetic agent.