2481-10-9Relevant articles and documents
Cysteine-based fluorescence "turn-on" sensors for Cu2+and Ag+
Haridas,Praveen Kumar,Suresh, Cherumuttathu H.
, p. 56539 - 56542 (2014)
We designed and synthesized twometal ion binding molecules 3a and 3b based on cysteine. In 3a, pyrene is used as a fluorescent probe, while 3b contains tryptophan, which acts as a fluorescent probe as well as facilitates metal ion binding. Detailed spectroscopic, calorimetric, microscopic and computational studies revealed the binding mode and the plausible structures of the complexes.
Asymmetric synthesis of β-lactams by intramolecular conjugate addition of serine and cysteine derivatives via memory of chirality
Hyakutake, Ryuichi,Yoshimura, Tomoyuki,Ueda, Yoshihiro,Hayashi, Kazuhiro,Furuta, Takumi,Kawabata, Takeo
, p. 1128 - 1147 (2019/07/31)
– The 4-exo-trig cyclization of axially chiral enolates generated from L-serine and L-cysteine dervatives proceeded predominately over β-elimination to give chiral β-lactams with contiguous tri- and tetrasubstituted carbon centers in up to 96% ee. The key to smooth production of β-lactams is the use of Cs2CO3and CF3CH2OH as a base and a proton source, respectively. A strongly electron-withdrawing Michael acceptor in the substrates was also critical for high enantioselectivity of the β-lactam formation.
