248248-98-8

Upstream product

• 5779-95-3 3,5-dimethylbenzaldehyde 
• 197229-98-4 5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine 

Downstream Products

• 311319-92-3 {[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-ylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 311319-94-5 N-{4-[1-(3,5-dimethyl-phenyl)-1-hydroxy-ethyl]-5-ethyl-2-methoxy-6-methyl-pyridin-3-yl}-2,2-dimethyl-propionamide 
• 248248-97-7 4-(3,5-dimethylbenzyl)-5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridine 
• 311319-88-7 N-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl]-propionamide 
• 311319-89-8 N-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl]-acetamide 
• 311319-90-1 N-[4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-2-oxo-1,2-dihydro-pyridin-3-yl]-formamide 
• 248247-37-2 4-(3,5-dimethyl-benzyl)-5-ethyl-6-methyl-3-methylamino-1H-pyridin-2-one 
• 248246-95-9 3-amino-4-(3,5-dimethylbenzyl)-5-ethyl-6-methylpyridin-2(1H)-one 
• 248246-92-6 3-amino-4-(3,5-dimethyl-benzoyl)-5-ethyl-6-methyl-1H-pyridin-2-one 
• 311319-87-6 1-(3,5-dimethylphenyl)-1-(5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridin-4-yl)methanone 
• 248248-99-9 acetic acid (3,5-dimethyl-phenyl)-[3-(2,2-dimethyl-propionylamino)-5-ethyl-2-methoxy-6-methyl-pyridin-4-yl]-methyl ester 

Relevant academic research and scientific papers

Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors

Several 4-benzyl analogues of 5-ethyl-6-methyl-4-(phenylthio)pyridin-2(1H)-ones were synthesized and evaluated for their anti-HIV-1 activities. Key transformations include metalation at the 4-C-position of 5-ethyl-2-methoxy-6-methyl-3-pivaloylaminopyridin

4-Benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: Optimization and in vitro evaluation against clinically important HIV mutant strains

The 4-benzyl and 4-benzoyl-3-dimethylaminopyridinones 13 and 14 are representatives of a new class of highly potent non nucleoside type inhibitors of HIV-1 reverse transcriptase. To conduct SAR studies on these two lead compounds, 102 new analogues were p