24836-01-9Relevant articles and documents
Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF 3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines
Yang, Wei,Huang, Liliang,Liu, Hong,Wang, Wei,Li, Hao
, p. 4667 - 4669 (2013/06/05)
We describe an unprecedented Pd(OCOCF3)2-catalyzed cascade process for the synthesis of highly functionalized 1,2,3,5- tetrasubstituted pyrroles with high efficiency. Unlike documented methods relying on preformed enamines and active halogenated terminal alkenes, the process employs simple 2-alkenal-dicarbonyls and primary amines in 'one-pot'. The Royal Society of Chemistry 2013.