24840-75-3

Basic information

• Product Name: 4-(4-CHLORO-PHENYL)-2-METHYL-THIAZOLE
• Synonyms: Thiazole,4-(p-chlorophenyl)-2-methyl- (8CI); 4-(4-Chlorophenyl)-2-methylthiazole
• CAS NO: 24840-75-3
• Molecular Formula: C₁₀H₈ClNS
• Molecular Weight: 209.6952
• Mol File: 24840-75-3.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 324.3°Cat760mmHg
• Flash Point: 149.9°C
• Appearance: /
• Density: 1.265g/cm³
• Vapor Pressure: 0.00047mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-CHLORO-PHENYL)-2-METHYL-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-CHLORO-PHENYL)-2-METHYL-THIAZOLE(24840-75-3)
• EPA Substance Registry System: 4-(4-CHLORO-PHENYL)-2-METHYL-THIAZOLE(24840-75-3)

Safety Data

• Hazardous Substances Data: 24840-75-3(Hazardous Substances Data)

Usage

General Description

4-(4-chloro-phenyl)-2-methyl-thiazole, also known as chlorophenylthiazole, is an organic compound with the molecular formula C10H8ClNS. It is a thiazole derivative with a chloro-phenyl group attached to the fourth carbon atom and a methyl group attached to the second carbon atom of the thiazole ring. Chlorophenylthiazole is used in the synthesis of pharmaceuticals, agrochemicals, and biologically active compounds. It exhibits antibacterial and antifungal properties, making it a potential candidate for the development of new antimicrobial agents. Additionally, this compound is also used in research and development to study the structure-activity relationship of thiazole derivatives and their potential applications in various fields.

InChI:InChI=1/C10H8ClNS/c1-7-12-10(6-13-7)8-2-4-9(11)5-3-8/h2-6H,1H3

Upstream product

• 1956-39-4 4-chloroacetophenone oxime 
• 108-24-7 acetic anhydride 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 62-55-5 thioacetamide 
• 27993-56-2 1-(4-chlorophenyl)-2-hydroxyethanone 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 99-91-2 para-chloroacetophenone 
• 25917-49-1 1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 937-20-2 p-chlorophenacyl chloride 

Downstream Products

• 66047-77-6 2-chloro-5-(2-methyl-thiazol-4-yl)-benzenesulfonyl chloride 
• 82672-29-5 C₃₂H₂₄Cl₂N₄S₂ 
• 24864-19-5 4-([1,1'-biphenyl]-4-yl)-2-methylthiazole 
• 1228794-43-1 4-(4'-chlorobiphenyl-4-yl)-2-methyl-1,3-thiazole 
• 66047-81-2 2-chloro-5-(2-methyl-thiazol-4-yl)-benzenesulfonamide 
• 82672-19-3 4-(p-chlorophenyl)-2-methylthiazole 3-oxide 

Relevant articles and documents

Gold complex containing diphosphine ortho-position carborane ligand as well as preparation method and application of gold complex

The invention relates to a gold complex containing a diphosphine ortho-position carborane ligand as well as a preparation method and an application of the gold complex. The gold complex is prepared bythe following method: dropwise adding an n-BuLi solutio

Exploration and Optimization of an Efficient One-pot Sequential Synthesis of Di/tri-substituted Thiazoles from α-Bromoketones, Thioacids Salt, and Ammonium Acetate

Exploration of scope of an optimized one-pot sequential procedure for preparing of 2,4-di- and 2,4,5-tri-substituted thiazoles has been accomplished. The synthesis was performed by the initial formation of a β-keto-thioester intermediate from nucleophilic substitution of α-bromoketones with thioacid potassium salts, followed by treatment with ammonium acetate and one equivalent of acetic acid in toluene to form imine intermediate eventually leading to cyclization yielding thiazoles. This procedure should be highlighted with a flexible way to control the substitution pattern around thiazole ring by choosing appropriately substituted α-bromoketones even containing acid labile functionality and thioacid potassium salts, and thus its applicability is very wide.

Efficient synthesis of 2,4-disubstituted thiazoles under grinding

A simple and convenient protocol is described for the preparation of 2,4-disubstituted thiazoles via a condensation reaction of -halo carbonyl compounds with thiourea or thioacetamide at room temperature, under grinding, in good yields.