24864-19-5Relevant academic research and scientific papers
Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions
Tang, Xiaodong,Yang, Jidan,Zhu, Zhongzhi,Zheng, Meifang,Wu, Wanqing,Jiang, Huanfeng
, p. 11461 - 11466 (2016/11/28)
A new strategy for thiazoles via copper-catalyzed [3+1+1]-type condensation reaction from oximes, anhydrides and potassiumthiocyanate (KSCN) is developed herein. The transformation has good functional group tolerance and various thiazoles were formed smoothly in good to excellent yields under mild reaction conditions. This process involves copper-catalyzed N-O/C-S bond cleavages, activation of vinyl sp2 C-H bond, and C-S/C-N bond formations which are under redox-neutral conditions as well as operational simplicity.
Microwave-assisted synthesis of 2-substituted 4-biarylyl-1,3-thiazoles by carbon-carbon cross-coupling in water
Dawood, Kamal M.,El-Deftar, Moteaa M.
experimental part, p. 1030 - 1038 (2010/06/16)
Suzuki-Miyaura and Heck-Mizoroki C-C cross-coupling reactions of 4-(halophenyl)-1,3-thiazoles with aryl(hetaryl)boronic acids or olefins, respectively, were investigated by using a catalytically active benzimidazole-based palladium(II) complex under both thermal and microwave heating conditions in water. The factors affecting the optimization of such reactions were evaluated.
