24858-28-4

Upstream product

• 7214-62-2 2-octyl nitrite 
• 108-94-1 cyclohexanone 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 141-52-6 sodium ethanolate 
• 765-87-7 cyclohexane-1,2-dione 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 931-57-7 1-methoxy-cyclohex-1-ene 
• 1424-22-2 1-cyclohexenyl acetate 
• 51425-61-7 2-Nitrosocyclohexanon-Dimer 
• 52540-36-0 2,2-dimethoxycyclohexanone oxime 

Downstream Products

• 4006-50-2 1,2,3,4,6,7,8,9-octahydrophenazine 
• 22374-48-7 2-aminocyclohexanone 
• 68226-54-0 C₁₂H₁₇NO₆ 
• 765-87-7 cyclohexane-1,2-dione 
• 28596-63-6 2-Phenylcarbamoyloxyimino-cyclohexanon 
• 1261632-16-9 C₁₅H₁₉NO₃ 
• 68226-52-8 C₁₅H₁₇NO₅S 
• 68226-51-7 C₁₃H₁₅NO₄S 
• 137731-31-8 N,N'-bis(2-hydroxyiminocyclohexylidene)propane-1,3-diamine 
• 66977-23-9 Cyclohexane-1,2-dione mono-(O-dimethoxymethyl-oxime) 
• 68297-93-8 C₁₉H₂₂N₂O₅S 

Relevant academic research and scientific papers

Metal nitrite: A powerful oxidizing reagent

An efficient and simple source of nitroso reagents and their oxidation reactions are described. The combination of a Lewis acid and a metal nitrite was applied to the oxidation of silyl enol ethers. Amino acid and peptide derivatives were easily accessed through in situ C-C bond cleavage of fully substituted silyl enol ethers upon oxidation.

Oxidation of α-oxo-oximes to nitrile oxides with hypervalent iodine reagents

Upon reaction with PhI(OAc)2, α-oxo-aldoximes are oxidized to α-oxo-nitrile oxides, while α-oxo-ketoximes are converted into nitrile oxides via the oxidative cleavage of the carbonyl-imino σ bond. The nitrile oxides thus formed were trapped wit

Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers

A novel class of tetrahydroindolone-derived semicarbazones has been discovered as potent Kv1.5 blockers. In in vitro studies, several compounds exhibited very good potency for blockade of Kv1.5. Compound 8i showed good selectivity for blockade of Kv1.5 vs hERG and L-type calcium channels. In an anesthetized pig model, compounds 8i and 10c increased atrial ERP about 28%, 18%, respectively, in the right atrium without affecting ventricular ERP.

ORGANIC SYNTHESIS USING ORGANOSULFUR-NITRITES AND -NITRATES

Thionitrites or thionitrates have been considered to be unstable.However, bulky groups' thio-NOn such as t-butylthio-nitrites and -nitrates have been readily synthesized and found to be stable enough for the use of the useful organic syntheses as an excellent nitrosation and diazotization reagents under mild conditions.Direct conversion of amines to the corresponding halides in the presence of copper halides (II), fluorination of heterocyclic amines in the presence of sodium tetrafluoroborate, α- oximation of methylene groups in ketones, facile cleavage of C=N bond to ketones, and desulfurization of thioacetals and thioketals, and other useful organic syntheses are described.

FACILE DIRECT α-OXIMATION OF KETONES USING t-BUTYL THIONITRATE

Various ketones containing methylene groups at α-position were found to react with t-butyl thionitrate at 0 deg C in tetrahydrofuran to give the corresponding α-oximino-ketones in excellent yield.