4006-50-2

Basic information

• Product Name: 1,2,3,4,6,7,8,9-octahydrophenazine
• Synonyms: 1,2,3,4,6,7,8,9-octahydrophenazine;Dicyclohexanopyrazine;Nsc19848
• CAS NO: 4006-50-2
• Molecular Formula: C₁₂H₁₆N₂
• Molecular Weight: 188.26884
• EINECS: 223-659-8
• Mol File: 4006-50-2.mol
• Article Data: 22

Chemical Properties

• Melting Point: 110-111 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 291.5°Cat760mmHg
• Flash Point: 109.9°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.00339mmHg at 25°C
• Refractive Index: 1.574
• PKA: 3.27±0.20(Predicted)
• CAS DataBase Reference: 1,2,3,4,6,7,8,9-octahydrophenazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4,6,7,8,9-octahydrophenazine(4006-50-2)
• EPA Substance Registry System: 1,2,3,4,6,7,8,9-octahydrophenazine(4006-50-2)

Safety Data

• Hazardous Substances Data: 4006-50-2(Hazardous Substances Data)

Usage

Uses

1,?2,?3,?4,?6,?7,?8,?9-?Octahydrophenazine is an impurity found in the rearragement of cyclohexane oxime to caprolactam.

InChI:InChI=1/C12H16N2/c1-2-6-10-9(5-1)13-11-7-3-4-8-12(11)14-10/h1-8H2

Upstream product

• 49774-71-2 1-ethoxy-1,2-epoxy-cyclohexane 
• 4829-73-6 1,2,3,4-tetrahydrophenazine 
• 6946-05-0 2-aminocyclohexanone hydrochloride 
• 111-69-3 hexanedinitrile 
• 7664-41-7 ammonia 
• 24858-28-4 cyclohexane-1,2-dione monooxime 
• 64-19-7 acetic acid 
• 492-99-9 1,2-cyclohexanedionedioxime 
• 92-82-0 Phenazin 
• 4018-65-9 3-Chlorocatechol 
• 533-60-8 cyclohexanone-2-ol 
• 120-80-9 benzene-1,2-diol 
• 931-17-9 1,2-Cyclohexanediol 
• 1056477-06-5 2-bromocyclohexanone 

Downstream Products

• 92-82-0 Phenazin 

Relevant articles and documents

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TWO PHENAZINE DERIVATIVES, POLYCARTINE A AND B FROM IDESIA POLYCARPA MAXIM (FLACOURTIACEAE)

Two hydrogenated phenazines have been isolated from the fruits of Idesia polycarpa Maxim and their structures were determined by spectral and chemical means.

Hydrogenation of N-Heteroarenes Using Rhodium Precatalysts: Reductive Elimination Leads to Formation of Multimetallic Clusters

A rhodium-catalyzed method for the hydrogenation of N-heteroarenes is described. A diverse array of unsubstituted N-heteroarenes including pyridine, pyrrole, and pyrazine, traditionally challenging substrates for hydrogenation, were successfully hydrogenated using the organometallic precatalysts, [(η5-C5Me5)Rh(N-C)H] (N-C = 2-phenylpyridinyl (ppy) or benzo[h]quinolinyl (bq)). In addition, the hydrogenation of polyaromatic N-heteroarenes exhibited uncommon chemoselectivity. Studies into catalyst activation revealed that photochemical or thermal activation of [(η5-C5Me5)Rh(bq)H] induced C(sp2)-H reductive elimination and generated the bimetallic complex, [(η5-C5Me5)Rh(μ2,η2-bq)Rh(η5-C5Me5)H]. In the presence of H2, both of the [(η5-C5Me5)Rh(N-C)H] precursors and [(η5-C5Me5)Rh(μ2,η2-bq)Rh(η5-C5Me5)H] converted to a pentametallic rhodium hydride cluster, [(η5-C5Me5)4Rh5H7], the structure of which was established by NMR spectroscopy, X-ray diffraction, and neutron diffraction. Kinetic studies on pyridine hydrogenation were conducted with each of the isolated rhodium complexes to identify catalytically relevant species. The data are most consistent with hydrogenation catalysis prompted by an unobserved multimetallic cluster with formation of [(η5-C5Me5)4Rh5H7] serving as a deactivation pathway.

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles

Herein we report the biocatalytic synthesis of substituted pyrazines and pyrroles using a transaminase (ATA) to mediate the key amination step of the ketone precursors. Treatment of α-diketones with ATA-113 in the presence of a suitable amine donor yielded the corresponding α-amino ketones which underwent oxidative dimerization to the pyrazines. Selective amination of α-diketones in the presence of β-keto esters afforded substituted pyrroles in a biocatalytic equivalent of the classical Knorr pyrrole synthesis. Finally we have shown that pyrroles can be prepared by internal amine transfer catalyzed by a transaminase in which no external amine donor is required.