66047-74-3

Usage

InChI:InChI=1/C10H8BrNS/c1-7-12-10(6-13-7)8-2-4-9(11)5-3-8/h2-6H,1H3

Upstream product

• 62-55-5 thioacetamide 
• 99-73-0 para-bromophenacyl bromide 
• 3581-87-1 2-methylthiazole 
• 1712-82-9 p-bromodibenzoyl peroxide 
• 98475-05-9 α-tosyloxy-4-bromoacetophenone 
• 16331-47-8 4-bromobenzoyl bromide 
• 59862-55-4 p-bromoacetophenone oxime 
• 108-24-7 acetic anhydride 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 66047-78-7 2-bromo-5-(2-methyl-thiazol-4-yl)-benzenesulfonyl chloride 
• 82672-20-6 4-(p-bromophenyl)-2-methylthiazole 3-oxide 
• 294620-60-3 4-(2-methylthiazol-4-yl)benzoic acid 
• 82672-30-8 C₃₂H₂₄Br₂N₄S₂ 
• 66047-82-3 2-bromo-5-(2-methyl-thiazol-4-yl)-benzenesulfonamide 
• 1228794-56-6 4-methyl-2-[4-[(E)-2-phenylvinyl]phenyl]-1,3-thiazole 
• 1228794-45-3 2-methyl-4-[4-(3-thienyl)phenyl]-1,3-thiazole 
• 1228794-57-7 butyl (2E)-3-[4-(2-methylthiazol-4-yl)phenyl]acrylate 
• 1228794-46-4 2-methyl-4-(4'-methylbiphenyl-4-yl)-1,3-thiazole 
• 1228794-43-1 4-(4'-chlorobiphenyl-4-yl)-2-methyl-1,3-thiazole 
• 108981-34-6 4-(4'-methoxybiphenyl-4-yl)-2-methyl-1,3-thiazole 
• 1228794-44-2 4-[3',4'-(methylenedioxy)biphenyl-4-yl]-2-methyl-1,3-thiazole 
• 24864-19-5 4-([1,1'-biphenyl]-4-yl)-2-methylthiazole 

Relevant academic research and scientific papers

A combine approach of chemical synthesis, biological evaluation and structural dynamics studies revealed thiazole substituted arylamine derivatives as potent FabH enzyme inhibitors

Bacterial FabH enzyme is a broad-spectrum antimicrobial target and can be used in the design of novel antibiotics. This study reports chemical synthesis of thiazole based amine compounds as FabH inhibitors, followed by biological evaluation, and computati

Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions

A new strategy for thiazoles via copper-catalyzed [3+1+1]-type condensation reaction from oximes, anhydrides and potassiumthiocyanate (KSCN) is developed herein. The transformation has good functional group tolerance and various thiazoles were formed smoothly in good to excellent yields under mild reaction conditions. This process involves copper-catalyzed N-O/C-S bond cleavages, activation of vinyl sp2 C-H bond, and C-S/C-N bond formations which are under redox-neutral conditions as well as operational simplicity.

A rapid and high-yielding synthesis of thiazoles and aminothiazoles using tetrabutylammonium salts

A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of tetrabutylammonium hexafluorophosphate (Bu4NPF6) at room temperature was developed. The products having high yields were formed rapidly (within 15 min). The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis data. The Japan Institute of Heterocyclic Chemistry.

Synthesis of heteroaromatic carboxylic acids by carbonylation of hetaryl halides with catalysts based on cobalt carbonyl modified with epoxides

A new method for the synthesis of heteroaromatic acids and their derivatives (esters and salts) by carbonylation of the corresponding halides was developed. Hetaryl halides were activated in alcoholic-alkali medium by highly active catalytic systems based on cobalt carbonyl modified with epoxides, developed previously for carbonylation of aryl halides.

Synthesis of thiazoles and aminothiazoles from β-keto tosylates under supramolecular catalysis in the presence of β-cyclodextrin in water

This is the first report on the supramolecular synthesis of thiazoles/aminothiazoles from β-keto tosylates and thioamide/thiourea in water in the presence of β-cyclodextrin in impressive yields. Formation of inclusion complexes was explained from 1H NMR studies. Copyright Taylor & Francis Group, LLC.

Aqueous phase synthesis of thiazoles and aminothiazoles in the presence of β-cyclodextrin

A simple and practical procedure for the aqueous phase preparation of thiazoles and aminothiazoles has been developed from phenacyl bromides and thioamide/thiourea in the presence of β-cyclodextrin.

An Improved of α-(Thioacylthio)methylphenyl-Ketones using Caesium Dithioates and a Convenient Synthesis of 2,4-Disubstituted 1,3-Thiazoles via the Ketones

α-(Thioacylthio)methylphenylketones were found to be obtained in almost quantitative yields from caesium dithioates and α-phenacyl bromide.Refluxing of these ketones with ammonium acetate in gracial acetic acid affords the corresponding 2,4-disubstituted