2487-49-2Relevant articles and documents
IDENTIFICATION OF 6α- AND 7α-HYDROXYESTRONE AS MAJOR METABOLITES OF ESTRONE AND ESTRADIOL IN PORCINE UTERUS
Maschler, I.,Ball, P.,Bayerkoehler, G.,Gaues, J.,Knuppen, R.
, p. 597 - 608 (2007/10/02)
Polar metabolites extracted from the effluents of viable porcine uterine strips superfused with either 6,7-3H-estrone or 6,7-3H-estradiol were identified as a 1 : 1 mixture of 6α-hydroxyestrone and 7α-hydroxyestrone by paper chromatography in various systems, derivatization and crystallizations to a constant specific activity.The hydroxylated compounds are the only derivatives detected after estrone superfusion.The major metabolite of estradiol released in short-time experiments is estrone followed by its 6α- and 7α-hydroxylated derivatives.