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7-hydroxyestrone (7-OH-E1) is a naturally occurring metabolite of the hormone estrone, which is one of the three main types of estrogens in the human body. It is formed through the enzymatic conversion of estrone by the cytochrome P450 enzyme system, particularly the CYP1A1 and CYP1B1 isoforms. 7-hydroxyestrone is considered a beneficial metabolite due to its antioxidant properties and its potential role in protecting against oxidative stress and inflammation. It is also believed to have a lower risk of promoting estrogen-related cancers compared to other estrogen metabolites, such as 16α-hydroxyestrone. The balance between 7-hydroxyestrone and 16α-hydroxyestrone is thought to be an important factor in maintaining overall health and reducing the risk of certain diseases.

2487-49-2

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2487-49-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2487-49-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2487-49:
(6*2)+(5*4)+(4*8)+(3*7)+(2*4)+(1*9)=102
102 % 10 = 2
So 2487-49-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H22O3/c1-18-7-6-13-12-3-2-11(19)8-10(12)9-15(20)17(13)14(18)4-5-16(18)21/h2-3,8,13-15,17,19-20H,4-7,9H2,1H3/t13-,14+,15?,17-,18+/m1/s1

2487-49-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,7α-dihydroxy-estra-1,3,5(10)-trien-17-one

1.2 Other means of identification

Product number -
Other names 3,7α-Dihydroxy-oestra-1,3,5(10)-trien-17-on

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:2487-49-2 SDS

2487-49-2Relevant academic research and scientific papers

IDENTIFICATION OF 6α- AND 7α-HYDROXYESTRONE AS MAJOR METABOLITES OF ESTRONE AND ESTRADIOL IN PORCINE UTERUS

Maschler, I.,Ball, P.,Bayerkoehler, G.,Gaues, J.,Knuppen, R.

, p. 597 - 608 (2007/10/02)

Polar metabolites extracted from the effluents of viable porcine uterine strips superfused with either 6,7-3H-estrone or 6,7-3H-estradiol were identified as a 1 : 1 mixture of 6α-hydroxyestrone and 7α-hydroxyestrone by paper chromatography in various systems, derivatization and crystallizations to a constant specific activity.The hydroxylated compounds are the only derivatives detected after estrone superfusion.The major metabolite of estradiol released in short-time experiments is estrone followed by its 6α- and 7α-hydroxylated derivatives.

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