24903-69-3

Upstream product

• 705-24-8 4,6-dichloro-2-(trifluoromethyl)pyrimidine 
• 672-47-9 2-trifluoromethyl-4,6-dihydroxypyrimidine 
• 262353-35-5 2-iodo-4-methoxypyrimidine 

Downstream Products

• 1546-80-1 2-trifluoromethyl-4-hydroxypyrimidine 

Relevant academic research and scientific papers

Preparation method of 4-chloro-2-trifluoromethyl pyrimidine

The invention discloses a preparation method of 4-chloro-2-trifluoromethyl pyrimidine (formula I). According to the preparation method, cheap and easily purchased methyl trifluoroacetate and malonamide are taken as the raw materials. The preparation method has the advantages that no pricy material is used, the reaction conditions are mild, the used equipment is simple, the EHS risk is little, the cost is low, and the preparation method is suitable for massive production.

Trifluoromethylation of haloarenes with a new trifluoro-methylating reagent Cu(O2CCF2SO2F)2

A new trifluoromethylating reagent Cu(O2CCF2SO2F)2, which easily decomposes to generate active CuCF3 species in DMF at room temperature, has been conveniently prepared from inexpensive starting materials on a large scale. This new reagent can be applied to efficiently trifluoromethylate a variety of haloarenes under mild conditions, providing good-to-excellent yields of the desired products.