24913-97-1Relevant academic research and scientific papers
Simple N,N-dimethyl phenylsulfonamides show potent anticonvulsant effect in two standard epilepsy models
Tanaka, Tomoyuki,Yajima, Nana,Kiyoshi, Tomoko,Miura, Yoshiki,Iwama, Seiji
, p. 94 - 97 (2016/12/09)
Optimization of the previously reported benzothiazine analogue A led to the identification of compound 1, which showed anti-convulsant activity in two golden standard animal models of seizure, the MES and scPTZ models. Structure-activity relationship investigation of compound 1 revealed compounds 2, 6 and 19 as attractive anti-epileptic drug (AED) candidates with potent anticonvulsant effect in both the MES and scPTZ models. As these compounds are structurally different from existing AEDs, determination of their mechanism of actions could provide clues to understanding current therapy-resistant seizures. Moreover, these simple phenylsulfoneamide compounds could be good starting points for searching broad spectrum AEDs by such in vivo screening.
Copper-mediated S-N formation via an oxygen-activated radical process: A new synthesis method for sulfonamides
Huang, Xin,Wang, Jichao,Ni, Zhangqin,Wang, Sichang,Pan, Yuanjiang
supporting information, p. 4582 - 4584 (2014/05/06)
Copper-mediated direct S-N formation using readily available starting materials via an oxygen-activated radical process has been developed. This method provides a novel and direct approach for synthesis of sulfonamides under air conditions. the Partner Organisations 2014.
Synthesis of aryl sulfonamides via palladium-catalyzed chlorosulfonylation of arylboronic acids
Debergh, J. Robb,Niljianskul, Nootaree,Buchwald, Stephen L.
, p. 10638 - 10641 (2013/08/23)
A palladium-catalyzed method for the preparation of sulfonamides is described. The process exhibits significant functional group tolerance and allows for the preparation of a number of arylsulfonyl chlorides and sulfonamides under mild conditions.
Herbicidal antidotes
-
, (2008/06/13)
Compositions comprising a non-phytotoxic antidotal compound and an antidotable herbicide and the use of the compositions to protect crop plants from injury due to the herbicide.
