24915-93-3

Upstream product

• 623-27-8 terephthalaldehyde, 
• 98-86-2 acetophenone 
• 860763-50-4 1,4-bis-(1-chloro-3-oxo-3-phenyl-propyl)-benzene 
• 64-17-5 ethanol 
• 103929-89-1 1,4-bis-(1,2-epoxy-3-oxo-3-phenyl-propyl)-benzene 
• 64-19-7 acetic acid 
• 3453-00-7 diethyl benzoylmethylphosphonate 

Downstream Products

• 34135-42-7 1,4-bis(1,3-diphenyl-4,5-dihydro-1H-pyrazol-5-yl)benzene 
• 96504-02-8 3-phenyl-5-[4-(3-phenyl-2-pyrazolin-5-yl)phenyl]-2-pyrazoline 
• 850408-23-0 (E)-3-[4-(4-Benzoyl-3-phenyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-1-phenyl-propenone 
• 850408-26-3 {5-[4-(4-benzoyl-3-phenyl-4,5-dihydro-isoxazol-5-yl)-phenyl]-3-phenyl-4,5-dihydro-isoxazol-4-yl}-phenyl-methanone 
• 850408-24-1 (E)-3-{4-[4-Benzoyl-3-(4-chloro-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenyl}-1-phenyl-propenone 
• 850408-27-4 [5-{4-[4-benzoyl-3-(4-chloro-phenyl)-4,5-dihydro-isoxazol-5-yl]-phenyl}-3-(4-chloro-phenyl)-4,5-dihydro-isoxazol-4-yl]-phenyl-methanone 
• 1119553-60-4 C₃₄H₃₆N₆S₂ 
• 1119553-62-6 C₃₈H₃₀N₈O₄S₂ 
• 1119553-61-5 C₄₂H₄₀N₆S₂ 
• 1119553-59-1 5,5'-(1,4-phenylene)bis(3-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamide) 
• 1119553-64-8 C₃₈H₄₄N₆S₂ 
• 1119553-68-2 C₄₀H₃₆N₆S₂ 
• 1119553-66-0 C₄₀H₃₆N₆S₂ 
• 1119553-63-7 C₃₆H₄₀N₆S₂ 

Relevant academic research and scientific papers

Study of 1,3-dipolar cycloaddition and ring contraction of new 1,4-phenylene-bis[1,5]benzothiazepine derivatives

Some 1,4-phenylene-bis[1,2,4]oxadiazolo-[5,4-d][1,5]benzothiazepine derivatives (4a-c) were synthesized by 1,3-dipolar cycloaddition reaction of benzohydroximinoyl chloride with 1,4-phenylene-bis(4-aryl)- 2,3-dihydro[1,5]benzothiazepine (2a-c); meanwhile,

Sustainable Catalytic Process with a High Eco-scale Score for the Synthesis of Novel Series of Bischalcones through Claisen–Schmidt Condensation

An efficient, sustainable, and green method for the synthesis of novel series of bischalcones was developed using an environmentally benign ionic liquid as catalyst under ultrasound irradiation. This new catalyst affords diverse bis-α, β-unsaturated keton

A Way to Improve Luminescent Efficiency of Bis-Chalcone Derivatives

Chalcone related compounds have been reported as a poor luminescence molecule due to the quenching processes from the intramolecular torsional motions and cis-trans isomerization in the α,β-unsaturated ketone moiety. Despite this limitation, we found a wa

Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors

The chalcone and bis-chalcone derivatives have been synthesized under sonication conditions via Claisen-Schmidt condensation with KOH in ethanol at room temperature (20–89%). The structures were established on the basis of NMR, IR, Single-crystal XRD, and

Synergistic antifungal effect of cyclized chalcone derivatives and fluconazole against Candida albicans

The occurrence of invasive fungal diseases, particularly in immunocompromised patients, is life-threatening and increases the economic burden. The rising problem of multi-drug resistance is becoming a major concern for clinicians. In addition, a repertoire of antifungal agents is far less in number than antibacterial drugs. To combat these problems, combination therapy has gained a lot of interest. We previously reported the synergistic interaction of some mono- and bis-dihydropyrimidinone and thione derivatives with fluconazole and amphotericin B for combination antifungal therapy. In this study we used the same approach and synthesized different azole and non-azole derivatives of mono-(M) and bis-(B) chalcones and evaluated their antifungal activity profile alone and in combination with the most commonly used antifungal drug-fluconazole (FLC)-against seven FLC susceptible and three FLC resistant clinically isolated Candida albicans strains. Based on the minimum inhibitory concentration results, the bis-derivatives showed lower MIC values compared to their mono-analogues. Both fractional inhibitory concentration index and isobologram results revealed mostly synergistic, additive or indifferent interactions between the tested compounds and FLC against different Candida isolates. None of the tested compounds showed any effect on energy dependent R6G efflux, revealing that they do not reverse the mechanism of drug efflux. However, surprisingly, these compounds profoundly decreased ergosterol biosynthesis and showed down regulation of ERG11 gene expression, which is the possible mechanism of reversal of azole drug resistance by these compounds. These results provide a platform for further research to develop pyrimidinone/thione ring containing compounds as promising new antifungal agents, which could be used in antifungal combination therapy.

Facile epoxidation of α, β-unsaturated ketones with urea-2,2-dihydroperoxypropane as a new oxidant

Abstract: Various aromatic α, β-unsaturated ketones were successfully transformed into their corresponding epoxides using urea-2,2-dihydroperoxypropane as the oxygen source for the first time. The reactions were carried out under mild alkaline conditions at room temperature in high yields and short reaction times. Graphical Abstract: [Figure not available: see fulltext.]

Metal-Free and Efficient Epoxidation of α,β-Unsaturated Ketones with 1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane as a Powerful Solid Oxidant

1,1,2,2-Tetrahydroperoxy-1,2-diphenylethane was used for the efficient and metal-free epoxidation of various α,β-unsaturated ketones, carried out under mild alkaline conditions at room temperature.

The influence of the push-pull effect and a π-conjugated system in conversion efficiency of bis-chalcone compounds in a dye sensitized solar cell

Chalcone and its related compounds are known to be π-conjugated compounds, which can be potentially used in different electronic areas include dye sensitized solar cell (DSSC). A total of six bis-chalcone compounds (1–6) have been synthesized using a Clai

Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives

A series of 1,4-phenylene-bis-chalcones 3a{3h were synthesized by the reaction of terephthalaldehyde with substituted arylketones in this study. The novel 1,4-phenylene-bis-pyrimidine-2-amine derivatives 5a{5h were obtained by the addition of guanidine hy

Aluminum chloride-catalyzed C-alkylation of pyrrole and indole with chalcone and bis-chalcone derivatives

The AlCl3-catalyzed alkylation of pyrrole (2) with chalcone (1a-i) at a ratio of 8:1 in the presence of 10 mol% AlCl3 gave the solely 2-alkyl pyrroles (3a-i) at room temperature for 12 in good yields. The same reaction was performed with pyrrole (2) and chalcone at a ratio of 1:3 in CH3CN at rt for 3 h to achieve 2,5-dialkyl pyrroles (4a-f). In addition, the reaction of the pyrrole (2) and indole (7) on 1,4-phenylene bis-chalcones (5a-g) at the ratio of 8:1 at rt for 24 h gave the double-addition products 6a-g and 8a-g in good yields, respectively. The structure of the products was confirmed by 1H and 13C NMR spectroscopy and elemental analysis.