249291-84-7

Basic information

• Product Name: 1-(2-fluoro-4-iodophenyl)ethan-1-one
• Synonyms: 1-(2-fluoro-4-iodophenyl)ethan-1-one
• CAS NO: 249291-84-7
• Molecular Weight: 264.038
• Mol File: 249291-84-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2-fluoro-4-iodophenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-fluoro-4-iodophenyl)ethan-1-one(249291-84-7)
• EPA Substance Registry System: 1-(2-fluoro-4-iodophenyl)ethan-1-one(249291-84-7)

Safety Data

• Hazardous Substances Data: 249291-84-7(Hazardous Substances Data)

Upstream product

• 13329-40-3 4-Iodoacetophenone 
• 896718-37-9 1-(4-iodophenyl)ethan-1-one O-methyl oxime 
• 1165872-80-9 1-(2-fluoro-4-iodo-phenyl)-ethanol 

Downstream Products

• 1165872-87-6 2-bromo-1-(2-fluoro-4-iodo-phenyl)-ethanone 

Relevant articles and documents

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

SUBSTITUTED HYDANTOINS

The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.