24948-31-0

Basic information

• Product Name: Benzenepropanoic acid, a-methyl-b-(phenylamino)-, methyl ester
• CAS NO: 24948-31-0
• Molecular Formula: C17H19NO2
• Molecular Weight: 269.343
• Mol File: 24948-31-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-methyl-b-(phenylamino)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-methyl-b-(phenylamino)-, methyl ester(24948-31-0)
• EPA Substance Registry System: Benzenepropanoic acid, a-methyl-b-(phenylamino)-, methyl ester(24948-31-0)

Safety Data

• Hazardous Substances Data: 24948-31-0(Hazardous Substances Data)

Upstream product

• 72658-03-8 (Z)-1-methoxy-1-(trimethylsiloxy)propene 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 34880-70-1 [1-methoxyprop-1-enyloxy]trimethylsilane 
• 538-51-2 benzylidene phenylamine 
• 292638-85-8 acrylic acid methyl ester 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 186581-53-3 diazomethane 
• 24948-35-4 (2RS:3RS)-3-anilino-2-methyl-3-phenyl-propionic acid 
• 72658-09-4 (E)-(1-methoxyprop-1-enyloxy)trimethylsilane 
• 140869-46-1 Trimethyl-((Z)-1-methylsulfanyl-propenylsulfanyl)-silane 
• 22628-31-5 syn-3-methyl-1,4-diphenylazetidin-2-one 
• 74-88-4 methyl iodide 

Downstream Products

• 17324-17-3 trans-3-methyl-1,4-diphenylazetidin-2-one 

Relevant articles and documents

Diastereoselective Synthesis of syn-β-Lactams Using Rh-Catalyzed Reductive Mannich-Type Reaction of α,β-Unsaturated Esters

The combination of Et2Zn and RhCl(PPh3)3 led to the facile generation of a rhodium-hydride complex (Rh-H) that catalyzed the 1,4-reduction of α,β-unsaturated esters. The resulting rhodium enolate performed as a Reformatsky-type reagent and reacted with various imines to give syn-β-lactams in good to excellent yields with high diastereoselectivity.

An efficient and mild bismuth triflate-catalysed three-component Mannich-type reaction

In the presence of a catalytic amount of Bi(OTf)3·4H 2O, aldehydes together with amines react with silyl enolates to afford the corresponding Mannich-type adducts smoothly. A wide variety of silyl enolates derived from ketones, as well as esters and thioesters, react rapidly to afford the β-amino ketones or the β-amino esters in high yields (up to 94%). The Royal Society of Chemistry.

One-pot synthesis of β-lactams from aldimines and ketene silyl acetals by tandem lewis base-catalyzed Mannich-type addition and cyclization

An efficient method for one-pot synthesis of β-lactams from aldimines and ketene silyl acetals by tandem Lewis base-catalyzed Mannich-type addition and cyclization, namely reaction of benzylideneanilines and trimethylsilyl enolates derived from esters or thioesters was established by using a Lewis base catalyst such as lithium acetate, N-lithio-2-pyrrolidone, potassium salt of phthalimide or lithium methoxide in DMF at room temperature to afford the corresponding β-lactams in good to high yields with moderate trans-selectivities. Copyright