249583-83-3

Basic information

• Product Name: 2-Pyridinecarbonitrile,5-(1-hydroxyethyl)-
• Synonyms: 2-Pyridinecarbonitrile,5-(1-hydroxyethyl)-;2-Pyridinecarbonitrile, 5-(1-hydroxyethyl)- (9CI)
• CAS NO: 249583-83-3
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16192
• Product Categories: ACETYLGROUP;PYRIDINE
• Mol File: 249583-83-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 341.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 13.33±0.20(Predicted)
• CAS DataBase Reference: 2-Pyridinecarbonitrile,5-(1-hydroxyethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarbonitrile,5-(1-hydroxyethyl)-(249583-83-3)
• EPA Substance Registry System: 2-Pyridinecarbonitrile,5-(1-hydroxyethyl)-(249583-83-3)

Safety Data

• Hazardous Substances Data: 249583-83-3(Hazardous Substances Data)

Upstream product

• 55675-95-1 3-(1,1-ethylenedioxyethyl)pyridine N-oxide 
• 84575-40-6 5-(1,1-ethylenedioxyethyl)pyridine-2-carbonitrile 
• 55676-25-0 3-(2-methyl-[1,3]dioxolan-2-yl)-pyridine 
• 249583-84-4 5-acetyl-2-pyridinecarbonitrile 

Relevant articles and documents

1-Imidazolylcarbonyloxy-substituted tetrahydroquinolines and pyridines: Synthesis and evaluation of P450 TxA2 inhibition

The title compounds are derived from our model describing structural requirements for strong P450 TxA2 inhibition. In the present paper the syntheses of the 1-imidazolylcarbonyloxy-substituted tetrahydroquinolines 1, 3, and 4, tetrahydro-naphthalene 2 and 3-ethylpyridines 5 and 6 are described. Using our P450 TxA2 inhibition assay, 1-6 were tested for enzyme inhibitory activity. Compound 1 (5-(1-imidazolylcarbonyloxy)-5,6,7,8- tetrahydroquinoline) turned out to be the most active derivative showing a potency similar to the reference compound dazoxiben (IC50 values 1.6 and 1.1 μM).