55676-25-0

Basic information

• Product Name: 3-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE
• Synonyms: 3-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE
• CAS NO: 55676-25-0
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.1891
• Mol File: 55676-25-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 260.7°Cat760mmHg
• Flash Point: 95.5°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 0.0195mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 3-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE(55676-25-0)
• EPA Substance Registry System: 3-(2-METHYL-1,3-DIOXOLAN-2-YL)PYRIDINE(55676-25-0)

Safety Data

• Hazardous Substances Data: 55676-25-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO2/c1-9(11-5-6-12-9)8-3-2-4-10-7-8/h2-4,7H,5-6H2,1H3

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 107-21-1 ethylene glycol 
• 626-55-1 3-Bromopyridine 
• 764-48-7 ethyleneglycol vinyl ether 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 56491-03-3 (+/-)-deplancheine 
• 73053-72-2 (+/-)-trans-1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester 
• 73053-73-3 (+/-)-trans-1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester 
• 115262-51-6 5-ethyl-1-(3-hydroxy-4-methoxyphenethyl)-2-piperidone 
• 115262-52-7 5-ethyl-1-(4-hydroxy-3-methoxyphenethyl)-2-piperidone 
• 115262-50-5 5-acetyl-1-(4-hydroxy-3-methoxyphenethyl)-2-piperidone 
• 115262-49-2 5-acetyl-1-(3-hydroxy-4-methoxyphenethyl)-2-piperidone 
• 115262-56-1 1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-5,6-dihydro-2(1H)-pyridinone 
• 115262-53-8 1-(3-benzyloxy-4-methoxyphenethyl)-5-ethyl-2-piperidone 
• 115262-65-2 1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-2-piperidone 
• 115262-67-4 1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-5,6-dihydro-2(1H)-pyridinone 
• 115288-08-9 1-(3-benzyloxy-4-methoxyphenethyl)-5-(1,1-ethylenedioxyethyl)-2-(1H)-pyridinone 
• 115262-72-1 1-(4-benzyloxy-3-methoxyphenethyl)-5-(1,1-ethylenedioxyethyl)-2-(1H)-pyridinone 
• 115262-66-3 1-(4-benzyloxy-3-methoxyphenethyl)-5-ethyl-3-phenylthio-2-piperidone 

Relevant articles and documents

Palladium-catalyzed regiocontrolled internal heteroarylation of electron-rich olefins with heteroaryl halides

A highly efficient palladium-catalyzed Heck coupling reaction of heteroaryl halides with electron-rich vinyl ether and hydroxyalkyl vinyl ethers is described. It was found that the choice of solvent, ligand, and reaction temperature had a fundamental influence on the regioselectivity and reactivity of the reaction, and the combination of Pd(OAc)2 and DPPF in ethylene glycol led to the most effective catalytic system. Under these conditions, a variety of heteroaryl halides reacted very quickly with electron-rich olefins to afford exclusively the branched products in good to excellent yields without employing triflates, halide scavengers, or ionic liquids.

Syntheses of an Antipsychotic Pyrroloisoquinoline from Areca Alkaloids

2,6-Dimethyl-3-ethyl-4,4a,5,6,7,8,8a,9-octahydro-4a,8a-trans-1H-pyrroloisoquinolin-4-one, a conformationally defined antipsychotic agent of current clinical interest, can be synthesized in a two-step, single-pot process from arecoline, a commercially available member of the areca alkaloid group.The yield is diminished by the competing, base-induced rearrangement of arecoline to 1,3-dimethyl-2-pyridone.This problem can be circumvented by using arecolone as the starting material.A convenient synthesis of arecolone from 3-acetylpyridine is described.A modifiedform of the Neber rearrangement was used to prepare 2-amino-3-pentanone hydrochloride for use in the Knorr pyrrole synthesis step of the process.Two isomeric pyrroloisoquinolines produced as minor byproducts were isolated and characterized as the cis- and trans- isomers.Characterization of the latter included an X-ray crystal structure determination.