249583-84-4

Basic information

• Product Name: 5-Acetyl-2-cyanopyridine
• Synonyms: 5-Acetyl-2-cyanopyridine;2-Pyridinecarbonitrile,5-acetyl-;2-Pyridinecarbonitrile, 5-acetyl- (9CI);5-acetyl-2-Pyridinecarbonitrile;5-Acetylpicolinonitrile
• CAS NO: 249583-84-4
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.14604
• Product Categories: ACETYLGROUP;PYRIDINE
• Mol File: 249583-84-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 336.5 °C at 760 mmHg
• Flash Point: 157.3 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 0.000112mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Acetyl-2-cyanopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Acetyl-2-cyanopyridine(249583-84-4)
• EPA Substance Registry System: 5-Acetyl-2-cyanopyridine(249583-84-4)

Safety Data

• Hazardous Substances Data: 249583-84-4(Hazardous Substances Data)

Usage

General Description

5-Acetyl-2-cyanopyridine, also known as 5-acetyl-2-pyridinecarbonitrile, is a chemical compound with the molecular formula C8H6N2O. It is a yellow solid that is used as a building block in organic synthesis and pharmaceutical research. 5-Acetyl-2-cyanopyridine is commonly used as a precursor in the production of various pharmaceuticals and agrochemicals. It is also used in the synthesis of various heterocyclic compounds. Additionally, this compound is known for its diverse potential applications in the pharmaceutical and chemical industries due to its unique chemical properties and reactivity.

InChI:InChI=1/C8H6N2O/c1-6(11)7-2-3-8(4-9)10-5-7/h2-3,5H,1H3

Upstream product

• 84575-40-6 5-(1,1-ethylenedioxyethyl)pyridine-2-carbonitrile 
• 350-03-8 methyl-3-pyridylketone 
• 151-50-8 potassium cyanide 
• 139042-59-4 1-(6-bromopyridin-3-yl)ethanone 
• 14188-94-4 3-acetylpyridine N-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 55675-95-1 3-(1,1-ethylenedioxyethyl)pyridine N-oxide 
• 55676-25-0 3-(2-methyl-[1,3]dioxolan-2-yl)-pyridine 

Downstream Products

• 65184-39-6 5-acetylpicolinic acid 
• 249583-83-3 5-(1-hydroxyethyl)pyridine-2-carbonitrile 

Relevant articles and documents

Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use

In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-, -L2-, and -L3- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (“Aβ”) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's disease, are also disclosed.

1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF

This invention provides a compound represented by the formula (I) :wherein R1 is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents;R2 is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents;n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I) , which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.