24959-20-4

Upstream product

• 94360-13-1 2-Bromo-2-[1-(4-chloro-phenyl)-3-oxo-3-phenyl-propyl]-malononitrile 
• 77609-09-7 3-(4-chlorophenyl)-2-cyano-5-phenyl-5-oxo-pentano-nitrile 
• 2648-61-5 2,2-dichloroacetophenone 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 
• 109-77-3 malononitrile 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 16883-69-5 N-phenacylpyridinium bromide 
• 1885-22-9 bromomalononitrile 

Relevant academic research and scientific papers

Indium(I) bromide-promoted stereoselective preparation of cyclopropanes via sequential aldol-type coupling/elimination/Michael-induced ring closure reaction from α,α-dichloroacetophenone and aldehydes

The indium enolate generated from indium(I) bromide and α,α-dichloroacetophenone reacts with aldehydes to produce (syn + anti)-2-chloro-3-hydroxy-propan-1-ones which can be converted to their trans-prop-2-en-1-ones derivatives upon reaction with an extra equivalent of InBr. The enones undergo Michael-induced ring closure reactions with an extra equivalent of the initial enolate to afford the corresponding cyclopropane derivatives, according to a sequenced reaction mechanism.

Stereoselective synthesis of functionalized cyclopropane derivatives via α-thiocyanate ketone-based three-component reaction

α-Thiocyanate ketone-based three-component reactions have been established for the stereoselective synthesis of functionalized electron-deficient trans-cyclopropanes. The multicomponent reactions were conducted by reacting readily available and inexpensiv

CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES

2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.