77609-09-7

Upstream product

• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 109-77-3 malononitrile 
• 24721-26-4 4-chlorochalcone 
• 70-11-1 α-bromoacetophenone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 78564-16-6 4-(4-Chlor-phenyl)-6-phenyl-2-thioxo-1,2-dihydro-pyridin-3-carbonitril 
• 94360-27-7 2-Bromo-4-(4-chloro-phenyl)-6-phenyl-nicotinonitrile 
• 94360-22-2 2-Chloro-2-[1-(4-chloro-phenyl)-3-oxo-3-phenyl-propyl]-malononitrile 
• 94360-13-1 2-Bromo-2-[1-(4-chloro-phenyl)-3-oxo-3-phenyl-propyl]-malononitrile 
• 24959-20-4 trans-2-benzoyl-3-(4'-chlorophenyl)-1,1-dicyanocyclopropane 
• 94360-44-8 4'-(4-Chloro-phenyl)-6'-phenyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile 
• 94360-51-7 4-(4-Chloro-phenyl)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-phenyl-nicotinonitrile 
• 1383253-45-9 methyl 2-(4-chlorophenyl)-4-oxo-4-phenylbutanoate 
• 1188358-52-2 (S)-3-(4-chlorophenyl)-2-cyano-5-phenyl-5-oxo-pentano-nitrile 
• 78564-25-7 C₃₆H₂₀Cl₂N₄S₂ 
• 143882-86-4 3-Amino-4-(4-chloro-phenyl)-6-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 143882-81-9 [4-(4-Chloro-phenyl)-3-cyano-6-phenyl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Cu(II)-Promoted Cascade Synthesis of Fused Imidazo-Pyridine-Carbonitriles

A Cu(II)-promoted synthesis of an aza-fused N-heterocycle having a benz-imidazopyridine scaffold is developed via an addition-cyclization reaction followed by an Ullmann-type C-N coupling between o-iodoanilines and γ-ketodinitriles. This protocol features a broad substrate scope, giving products in 32-84% yields. The compounds show excellent photoluminescence properties having two absorption maxima in the region between 270-280 and 338-350 nm and emission maxima in the range of 502-533 nm. The HOMO-LUMO energy gap of 3.49-3.57 eV was determined using Gaussian 09 at the B3LYP/6-31G (d, p) basis set level. We also demonstrated a few postsynthetic modifications.

Visible-light-accelerated pd-catalyzed cascade addition/ cyclization of arylboronic acids to γ- And β-ketodinitriles for the construction of 3-cyanopyridines and 3-cyanopyrrole analogues

The one-pot synthetic strategies for 2,4,6-triarylnicotinonitriles and 2,5-diaryl-1H-pyrrole-3-carbonitriles have been accomplished via a Pd-catalyzed coupling of arylboronic acid with 2-(3-oxo-1,3-diarylpropyl)malononitrile and 2-(2-oxo-2- arylethyl)malo

Conjugate addition of malononitrile on chalcone: Biocatalytic [Formula presented] bond formation

An efficient, cost effective and environmentally friendly protocol has been developed for the Michael addition of malononitrile on 1,3-diaryl-2-propen-1-ones (Chalcones) using very cheaper, easily available natural catalyst, baker's yeast. The whole cells of yeast excellently worked in nonaqueous medium, ethanol without decrease in catalytic activity.

One-Pot Quinine-Catalyzed Synthesis of α-Chiral γ-Keto Esters: Enantioenriched Precursors of cis-α,γ-Substituted-γ-Butyrolactones

A highly enantioselective one-pot synthesis of important building blocks, α-chiral γ-keto esters, has been developed by combining a quinine-catalyzed Michael addition of malononitrile to trans-enones followed by magnesium monoperoxyphthalate (MMPP) oxidat

Quinine catalysed asymmetric Michael additions in a sustainable solvent

Diethyl carbonate is shown to be a suitable, sustainable solvent in which to carry out quinine catalysed asymmetric Michael additions of malononitriles to enones. Both malonitrile and α-substituted malononitriles can be used as substrate and the results suggest that π-π stacking interactions between the (hetero)aromatic rings of the catalyst and substrates are important in determining the degree of asymmetric induction.

A mild and convenient one-pot synthesis of 4,6-diaryl- 3-aminoisoxazolo[3, 4-b]pyridines

We have developed a convenient method for the synthesis of a series of new 4,6-diaryl-3-aminoisoxazolo[3,4-b]pyridines through one-pot reaction starting from the easily available chalcones, malononitrile, and hydroxylamine. This class of compounds might h

An active and selective heterogeneous catalytic system for Michael addition

Potassium fluoride doped natural zeolite was found to be an efficient and selective solid base catalyst for 1,4-Michael addition. The catalyst is easily prepared and the workup procedure simplified by simple filtration. All products were obtained in high

The Michael addition of active methylene compounds to chalcone derivatives using a catalytic amount of iodine and K2CO3 at room temperature

A convenient method for the Michael addition of active methylene compounds to chalcone derivatives has been developed using the inexpensive and environmentally friendly reagent I2/K2CO3 at room temperature. The method is m

Back to natural cinchona alkaloids: Highly enantioselective Michael addition of malononitrile to enones

An efficient and convenient highly enantioselective Michael addition of malononitrile to enones has been developed by using quinine as the organocatalyst. The adducts were isolated in excellent yield and high asymmetric induction (up to 95% ee). An easy r

Michael addition of active methylene compounds to α, β-unsaturated carbonyl compounds under the influence of molecular sieves in dimethyl sulfoxide

The Michael addition of active methylene compounds to α, β-unsaturated carbonyl compounds in the presence of MS 4A in dimethyl sulfoxide proceeds smoothly to afford the corresponding 1,4-addition products in good to high yields. Copyright