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24960-16-5

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24960-16-5 Usage

General Description

2-Acetamido-2-deoxy-D-galactonolactone, also known as N-acetylgalactosamine, is a chemical compound derived from galactose. It is a key component of glycoproteins and glycolipids, playing a crucial role in cell adhesion and recognition processes. N-acetylgalactosamine is involved in the biosynthesis of blood group antigens and serves as a precursor for the formation of various complex carbohydrates. It is also a significant part of mucin glycoproteins, which are essential for maintaining the protective barrier of epithelial tissues. In addition, N-acetylgalactosamine is found in the structure of hyaluronic acid, a key component of connective tissues, and plays a key role in various biological processes, making it a valuable molecule in biochemistry and medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 24960-16-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,9,6 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 24960-16:
(7*2)+(6*4)+(5*9)+(4*6)+(3*0)+(2*1)+(1*6)=115
115 % 10 = 5
So 24960-16-5 is a valid CAS Registry Number.

24960-16-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4,5-Dihydroxy-6-(hydroxymethyl)-2-oxotetrahydro-2H-pyran-3-yl] acetamide (non-preferred name)

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24960-16-5 SDS

24960-16-5Downstream Products

24960-16-5Relevant articles and documents

Crystal structures and functional studies clarify substrate selectivity and catalytic residues for the unique orphan enzyme N-acetyl-D-mannosamine dehydrogenase

Sola-Carvajal, Agustin,Gil-Ortiz, Fernando,Garcia-Carmona, Francisco,Rubio, Vicente,Sanchez-Ferrer, Alvaro

, p. 499 - 511 (2014)

NAMDH (N-acetyl-D-mannosamine dehydrogenase), from the soil bacteroidete Flavobacterium sp. 141-8, catalyses a rare NAD+ -dependent oxidation of ManNAc (N-acetyl-Dmannosamine) into N-acetylmannosamino-lactone, which spontaneously hydrolyses into N-acetylmannosaminic acid. NAMDH belongs to the SDR (short-chain dehydrogenase/reductase) superfamily and is the only NAMDH characterized to date. Thorough functional, stability, site-directed mutagenesis and crystallographic studies have been carried out to understand better the structural and biochemical aspects of this unique enzyme. NAMDH exhibited a remarkable alkaline pH optimum (pH 9.4) with a high thermal stability in glycine buffer (Tm =64°C) and a strict selectivity towards ManNAc and NAD+ . Crystal structures of ligand-free and ManNAc- and NAD + -bound enzyme forms revealed a compact homotetramer having point 222 symmetry, formed by subunits presenting the characteristic SDR α3β7α3 sandwich fold. A highly developed C-terminal tail used as a latch connecting nearby subunits stabilizes the tetramer. A dense network of polar interactions with the substrate including the encasement of its acetamido group in a specific binding pocket and the hydrogen binding of the sugar 4OH atom ensure specificity for ManNAc. The NAMDH-substrate complexes and site-directed mutagenesis studies identify the catalytic tetrad and provide useful traits for identifying new NAMDH sequences.

Chemo-enzymatic approach to access diastereopure α-substituted GlcNAc derivatives

Wang, Su-Yan,Laborda, Pedro,Lu, Ai-Min,Wang, Meng,Duan, Xu-Chu,Liu, Li,Voglmeir, Josef

, p. 423 - 434 (2017/08/23)

The formation of diastereopure α-substituted GlcNAc derivatives in a simple and straightforward way is a challenging task. Herein, we report the chemical synthesis of diastereomeric α/β-substituted GlcNAc derivatives under non-anhydrous atmosphere using u

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