249611-07-2

Upstream product

• 109-73-9 N-butylamine 
• 249610-98-8 (2R,4S,5R)-(+)-Methyl 3-(2-chloroacetyl)-5-methyl-2-phenyl-1,3-oxazolidine-4-carboxylate 
• 100-52-7 benzaldehyde 

Downstream Products

• 249611-14-1 (1R)-(-)-1-[(2R)-1-Benzyl-4-butylpiperazin-2-yl]ethan-1-ol 

Relevant academic research and scientific papers

A facile synthesis of enantiomerically pure 1-(piperazin-2-yl)ethan-1-ol derivatives from (2s,3r)-threonine

Starting from the proteinogenic amino acid (2S,3R)-threonine (4) a novel method for the preparation of enantiomerically pure 1-(1-benzylpiperazin-2- yl)ethan-1-ols with various substituents in position 4 (15 - 20) is described. The sequence involves as key step the LiAlH4 reduction of the bicyclic piperazinediones 11a,b-14a,b which establishes the 1-benzyl protective group and simultaneously liberates the 1-hydroxyethyl side chain for further transformations.