24967-77-9

Upstream product

• 65447-26-9 (E)-1-benzylidene-2-(4-iodophenyl)hydrazine 
• 100-47-0 benzonitrile 
• 540-37-4 p-aminoiodobenzene 
• 55-21-0 benzamide 

Downstream Products

• 1459721-90-4 N′-(4-iodophenyl)-N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)benzimidamide 
• 1403990-53-3 N-(7-oxo-1,3-diphenyl-1,7-dihydrobenzo[e][1,2,4]triazin-6-yl)benzamide 
• 1459722-03-2 8-(4-iodophenyl)-1,3,7-triphenyl-4,8-dihydro-1H-imidazo[4,5-g][1,2,4]benzotriazin-4-yl 
• 1459721-84-6 N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e][1,2,4]triazin-6-yl)-N′-phenylbenzimidamide 
• 1459721-94-8 N′-n-hexyl-N-(1,7-dihydro-7-oxo-1,3-diphenylbenzo[e]-[1,2,4]triazin-6-yl)benzimidamide 
• 1459721-97-1 1,3,7,8-tetraphenyl-4,8-dihydro-1H-imidazo[4,5-g][1,2,4]benzotriazin-4-yl 
• 1459722-05-4 8-n-hexyl-1,3,7-triphenyl-4,8-dihydro-1H-imidazo[4,5-g][1,2,4]benzotriazin-4-yl 
• 1459721-83-5 1,3,7-triphenyl-1,4-dihydro[1,3]oxazolo[4,5-g][1,2,4]benzotriazin-4-yl 
• 1242182-89-3 6-iodo-2-phenyl-4-[(triisopropylsilyl)methyl]quinazoline 
• 1198464-00-4 (5-iodo-2-phenyl-1H-indol-3-yl)(phenyl)methanone 
• 3526-49-6 N-(4-iodophenyl)benzylamine 
• 55-21-0 benzamide 
• 1449576-72-0 7-iodo-2-phenyl-3H-imidazo[4,5-b]quinoline-9-carbonitrile 
• 1449612-25-2 (Z)-2-{4-[(4-iodophenyl)imino]-2-phenyl-1H-imidazol-5(4H)-ylidene}malononitrile 

Relevant academic research and scientific papers

Base-Mediated Amination of Alcohols Using Amidines

Novel and efficient base-mediated N-alkylation and amidation of amidines with alcohols have been developed, which can be carried out in one-pot reaction conditions, which allows for the synthesis of a wide range of N-alkyl amines and free amides in good to excellent yields with high atom economy. In contrast to borrowing hydrogen/hydrogen autotransfer or oxidative-type N-alkylation reactions, in which alcohols are activated by transition-metal-catalyzed or oxidative aerobic dehydrogenation, the use of amidines provides an effective surrogate of amines. This circumvents the inherent necessity in N-alkylation of an oxidant or a catalyst to be stabilized by ligands.

Direct Synthesis of 3-Acylindoles through Rhodium(III)-Catalyzed Annulation of N-Phenylamidines with α-Cl Ketones

In the present study, a novel synthetic strategy to directly produce versatile 3-acylindoles through Rh(III)-catalyzed C-H activation and annulation cascade of N-phenylamidines with α-Cl ketones was developed, in which α-Cl ketones serve as unusual one-carbon (sp3) synthons. This strategy features high regioselectivity, efficiency, wide substrate tolerance, and mild reaction conditions, which further underscore its synthetic utility in drug molecule synthesis.

Reinvestigating the synthesis of N-arylbenzamidines from benzonitriles and anilines in the presence of AlCl3

The preparation of N-phenylbenzamidine 3a from the reaction between benzonitrile Ia and aniline in the presence of AId3 is reinvestigated with respect to mode of reagent addition, reaction temperature and Lewis acid catalysis. Pre-forming the nitrile-Lewis acid complex prior to the addition of aniline allows for milder reaction conditions, allowing for the higher yielding synthesis of N-phenylbenzamidine 3a (83%). Using these modified conditions several N-(4-substituted phenyl)benzamidines can be prepared including the N-(4-methoxyphenyl)benzamidine 3b (93%) and the previously unobtainable 2-amino-N-(4-methoxyphenyl)benzamidine 31(56%). All new compounds are fully characterised.