249762-40-1Relevant academic research and scientific papers
Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase
Mahboobi, Siavosh,Teller, Steffen,Pongratz, Herwig,Hufsky, Harald,Sellmer, Andreas,Botzki, Alexander,Uecker, Andrea,Beckers, Thomas,Baasner, Silke,Sch?chtele, Christoph,überall, Florian,Kassack, Matthias U.,Dove, Stefan,B?hmer, Frank-D.
, p. 1002 - 1018 (2007/10/03)
The novel lead bis(1H-2-indolyl)methanone inhibits autophosphorylation of platelet-derived growth factor (PDGF) receptor tyrosine kinase in intact cells. Various substituents in the 5- or 6-position of one indole ring increase or preserve potency, whereas
Indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferation
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, (2008/06/13)
The invention relates to tyrosine kinase inhibitors of the bis-indolyl compound type of the general formula I: pharmaceuticals containing them and their use for the treatment of malignant and other diseases based on pathological cell proliferation.
Homoarcyriaflavin: Synthesis of Ring-Expanded Arcyriaflavin Analogues
Mahboobi, Siavosh,Burgemeister, Thomas,Dove, Stefan,Kuhr, Sabine,Popp, Alfred
, p. 8130 - 8137 (2007/10/03)
The construction of the ring-expanded carbazole system, forming arcyriaflavin homologues, is efficiently accomplished by the reaction of 2,2′-bridged bis-indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione derivatives under Grignard conditions. A ring size of up to nine members in the central ring is achievable. Substitutions either at the indole system or at the imide-N are also possible. The conformation of homoarcyriaflavins as a cross-link between the rigid arcyriaflavins and the flexible arcyriarubins was investigated by NMR, X-ray, and semiempiric quantum chemical calculation methods.
