2499-58-3

Usage

Uses

Used in Adhesives Industry:
N-Heptyl acrylate is used as a monomer for the production of adhesives, contributing to their bonding properties and performance characteristics.
Used in Coatings Industry:
In the coatings industry, N-heptyl acrylate is used as a component in the formulation of coatings, enhancing their durability, adhesion, and resistance to environmental factors.
Used in Sealants Industry:
N-Heptyl acrylate is utilized as a monomer in the creation of sealants, which are essential for sealing joints and preventing the passage of substances such as water, air, and gases.
Used in Textile and Leather Industry:
N-HEPTYL ACRYLATE is used as a monomer in the production of textiles and leather, where it helps in achieving desired properties such as flexibility, strength, and resistance to wear.
Used as a Chemical Intermediate:
N-Heptyl acrylate also serves as a chemical intermediate in the synthesis of other organic compounds, playing a crucial role in the development of new materials and products.
It is important to handle N-heptyl acrylate with care due to its potential hazards, which include skin, eye, and respiratory system irritation. Appropriate safety measures should be taken during its use to mitigate these risks.

InChI:InChI=1/C10H18O2/c1-3-5-6-7-8-9-12-10(11)4-2/h4H,2-3,5-9H2,1H3

Upstream product

• 111-70-6 n-heptan1ol 
• 292638-85-8 acrylic acid methyl ester 
• 3840-67-3 sulfuric acid mono-(2-carbamoyl-ethyl) ester 
• 109182-96-9 Acrylic acid 7-iodo-heptyl ester 
• 79-10-7 acrylic acid 
• 10160-24-4 7-bromoheptyl alcohol 
• 629-30-1 1,7-heptandiol 
• 89940-48-7 7-iodo-1-heptanol 
• 814-68-6 acryloyl chloride 

Downstream Products

• 132876-46-1 1-(2-Heptyloxycarbonyl-ethyl)-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment

Targeted protein degradation using small molecules is an intriguing strategy for drug development. The marine sesterterpene compound MHO7 had been reported to be a potential ERα degradation agent. In order to further improve its biological activity, two series of novel MHO7 derivatives with long side chains were designed and identified as novel selective estrogen receptor down-regulators (SERDs). The growth inhibition activity of the novel SERD compounds were significantly affected by the type and length of the side chain. Most of the derivatives were significantly more potent than MHO7 against both drug-sensitive and drug-resistant breast cancer cells. Among them, compound 16a, with IC50 values of 0.41 μM against MCF-7 cell lines and 9.6-fold stronger than MHO7, was the most potential molecule. A whole-genome transcriptomic analysis of MCF-7 cells revealed that the mechanism of 16a against MCF-7 cell was similar with that of MHO7. The estrogen signaling pathway was the most affected among the disturbed genes, but the ERα degradation activity of 16a was observed higher than that of MHO7. Other effects of 16a were confirmed similar with MHO7, which means that the basic mechanisms of the derivatives are the same with the ophiobolin backbone, i.e. the degradation of ERα is mediated via proteasome-mediated process, the induction of apoptosis and the cell cycle arrest at the G1 phase. Meanwhile, a decrease of mitochondrial membrane potential and an increase of cellular ROS were also detected. Based on these results, as a novel modified ophiobolin derived compound, 16a may warrant further exploitation as a promising SERD candidate agent for the treatment of breast cancer.

Free-solvent Michael addition of glycerol to acrylic compounds

In this paper, we report the study of the free-solvent nucleophilic addition of alcohols and glycerol to acrylic compounds, in the presence of catalytic bases. With acrylates, Michael addition and transesterification are in competition: only the PTC reaction with t-butyl acrylate gave trifunctionalized glycerol. With acrylonitrile, the cyanoethylation of glycerol varies with catalysts, temperature, time of reactions and amounts of acrylonitrile. Mono functionalisation of glycerol can be obtained in 28% yield. The optimization of the free-solvent Michael addition of glycerol to acrylonitrile (3.4 equiv., 4 mol% NaOH, 5 h) leads to TCEG (tricyanoethylglycerol, 88% yield, 99% purity) without HCl neutralisation, chlorinated solvents or purification (chromatography or distillation). TCEG can be used as a prochiral core of G0.5 dendrimers.

A New Synthetic Method of Macrocyclic Lactones from ω-Iodoalkylacrylates

When the photostimulated cyclization reaction of ω-iodoalkylacrylates was performed in the presence of metal hydride complexes such as sodium cyanoborohydride (NaBH3CN), sodium borohydride (NaBH4) and potassium borohydride (KBH4), the corresponding macrocyclic lactones were produced.The use of NaBH3CN led to the highest yield of lactones.