249922-30-3Relevant articles and documents
Cyclization of benzyne-tethered alkyllithiums: Preparation of 3-substituted benzocyclobutenes and 5-substituted tetralins
Bailey, William F.,Longstaff, Sarah C.
, p. 6899 - 6901 (2007/10/03)
A five-step, one-pot preparation of isomerically pure 3-substituted benzocyclobutenes or 5-substituted tetralins in 20-40% yield from the appropriate α-(2-fluorophenyl)-ω-iodoalkane, involving generation and subsequent 4-or 6-exo cyclization of a benzyne-tethered alkyllithium, is described.
