250226-98-3

Upstream product

• 213815-24-8 ((2R,4S,5R)-4-Allyl-2-phenyl-[1,3]dioxan-5-yloxy)-tert-butyl-dimethyl-silane 
• 79364-36-6 (2R,3S)-hex-5-ene-1,2,3-triol 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 213815-23-7 (E)-4-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-but-2-enoic acid methyl ester 
• 193970-21-7 [(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-acetaldehyde 

Downstream Products

• 1032746-03-4 C₁₅H₁₈O₄ 
• 250226-99-4 C₁₅H₂₀O₅ 
• 250227-00-0 C₁₈H₂₂O₆ 
• 250227-02-2 (7S,8R)-7-Benzyloxy-8-benzyloxymethyl-oxocan-2-one 
• 250227-01-1 (6S,7R)-6,8-Bis-benzyloxy-7-hydroxy-octanoic acid 
• 865363-93-5 (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol monohydrate 
• 213815-24-8 ((2R,4S,5R)-4-Allyl-2-phenyl-[1,3]dioxan-5-yloxy)-tert-butyl-dimethyl-silane 

Relevant academic research and scientific papers

Synthesis of Luffarin L and 16- epi -Luffarin L Using a Temporary Silicon-Tethered Ring-Closing Metathesis Reaction

The first synthesis of luffarin L (1) and 16-epi-luffarin L (2) by a silicon-tethered ring closing metathesis as a key step has been achieved. The stereochemistry and absolute configuration of the natural sesterterpenolide luffarin L (1) and a new route f

Nine-Step Stereoselective Synthesis of Islatravir from Deoxyribose

A stereoselective nine-step synthesis of the potent HIV nucleoside reverse transcriptase translocation inhibitor (NRTTI) islatravir (EfdA, MK-8591) from 2-deoxyribose is described. Key findings include a diastereodivergent addition of an acetylide nucleophile to an enolizable ketone, a chemoselective ozonolysis of a terminal olefin and a biocatalytic glycosylation cascade that uses a unique strategy of byproduct precipitation to drive an otherwise-reversible transformation forward.

Synthetic studies on maitotoxin. 2. Stereoselective synthesis of the WXYZA -ring system

The stereoselective synthesis of the WXYZA -ring system of maitotoxin has been accomplished via a linear synthetic approach, in which key reactions were Sml2-induced cyclization of ss-alkoxyacrylate for the construction of the A -, Y-, and X-rings and 6-endo cyclization of hydroxy vinylepoxide for that of the Z- and W-rings.

Harnessing glycal-epoxide rearrangements: The generation of the AB, EF, and IJ rings of adriatoxin

(Chemical Equation Presented) Climbing the ladder: The generation of three bicyclic subunits ofadriatoxin (see structure) was accomplished by using glycal-epoxide rearrangements, glycal-Claisen rearrangements, and C-glycoside-forming reactions.

A general method for convergent synthesis of polycyclic ethers based on Suzuki cross-coupling: Concise synthesis of the ABCD ring system of ciguatoxin

(matrix presented) A general method for convergent assembly of polyether structure has been developed based on palladium(0)-mediated Suzuki cross-coupling reaction of alkylboranes with cyclic ketene acetal phosphates. The present method allowed for coupli